Foad Rouhani at King's College Hospital and the Francis Crick Institute was one of the senior authors on the study.

We've known for a long time through clinical experience that children who've had previous cancers who then go on and survive can have medical problems further down the line many years later, secondary cancers, for example, that arise or diseases related to the liver.

Um, and so the question we're really we're trying to ask with this work was, can we somehow understand what happens at the time of their initial treatment, which may in some way explain what then happens years down the line?

in the course of trying to treat their cancer?

Exactly.

Exactly.

So one of the techniques that we apply in these sort of scenarios is to try and detect patterns of changes within DNA.

Mutations, the change of the DNA, and mutational signatures of these patterns.