
Eric Sontheimer
CRISPR pioneer and Pillar Chair in Biomedical Research at UMass Chan Medical School, co-founder of Intellia Therapeutics.
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Jul 29, 2026
CRISPR’s 'Wild West': Erik Sontheimer on the evolution of genome editing
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What was it like, you know, being at the leading edge of all of that, at the forefront of all of that?

Eric SontheimerGUEST
Again, I think, you know, we had a sense that this was a great place to be w- in terms of where we were working, and that it was definitely taking off and becoming something big.

Eric SontheimerGUEST
It, it took us a while to get a sense of exactly how big it was going to get.

Eric SontheimerGUEST
Yeah, so the immediate aftermath, uh, the paper certainly got some good attention, but at the time, there were still relatively few labs working on CRISPR.

Eric SontheimerGUEST
About a month or so before we submitted our paper, another paper came out from John Van der Oost's lab that showed that CRISPR had RNA guides that were essential for the overall process.
25 MINS LATER

Soren HoughHOST
Where do you see this going? Do you think that the innovation's gonna come from these new technologies, or do we need to refine the ones that we already have? And to what end? I guess ultimately it's for the clinic, right?
