What was the side effect that-

So, so bisphosphonates were the first FDA-approved, uh, therapy in the United States for osteoporosis back in nineteen ninety-five.

That was alendronate.

And in about two thousand eight, I believe it was Diane Sawyer, if people remember who she is, she, she reported on the news network that on TV, 'cause we still had TV back then, [laughs] that, that, that, uh, I think it was somebody in New York just stepped off the subway and suffered a thigh fracture without falling down.

And so then they started noticing that people who had been on alendronate or the brand name Fosamax for longer periods of time seemed to be at risk of, uh, developing a spontaneous fracture of their thigh bone, which is really unfortunate for the field because that's-- you take the medicine to prevent the fracture, and here's the medication looking like it's causing the fracture, which in some people it does.

So, so that caused, um, a lot of people not to take the medicine.

Um, there was also earlier in the-- I'd say around two thousand five or six, uh, there were reports of what they call osteonecrosis of the jaw, where people would then be on this drug and then have a tooth pulled, and then the pu- the bone in the jaw not healing, becoming what we call necrotic or dead tissue in the mouth, which does not sound fun, you know, at all.

What's one thing you want to leave the listener with today from our conversation? If one thing was going to land.