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Deborah Kado

Deborah Kado

Researcher

Oct 26, 2026

37:29
If someone wants to get to 70 or 80, and have good power, what's the key to that?
37:36
Yeah, it's doing it.
37:39
It's moving, but I guess there are different types of muscle fibers, and it's the fast twitch fibers that tend to go down with age, and those are the ones that allow you to generate short bursts of energy.
37:53
So I think it's those, but I would say things that require kind of quick movement and reactivity, jumping.
38:00
So how did we assess power in the study you're referring to? I think the reason why we didn't see power-related outcomes is because it was, how do you measure that? But the way we did it was with a force plate.
38:13
And so we could separate the strength from the velocity and really look at the power itself.
38:19
And that was the metric.
38:36
Point being that it's not just about, can you slowly move the heaviest weight possible? That these other types of exercises where the weight and load might be a little bit less, but you're moving quicker are complimentary and additive and important when it comes to if you have a trip, can you catch yourself?
50:15
What was the side effect that-
50:17
So, so bisphosphonates were the first FDA-approved, uh, therapy in the United States for osteoporosis back in nineteen ninety-five.
50:28
That was alendronate.
50:29
And in about two thousand eight, I believe it was Diane Sawyer, if people remember who she is, she, she reported on the news network that on TV, 'cause we still had TV back then, [laughs] that, that, that, uh, I think it was somebody in New York just stepped off the subway and suffered a thigh fracture without falling down.
50:48
And so then they started noticing that people who had been on alendronate or the brand name Fosamax for longer periods of time seemed to be at risk of, uh, developing a spontaneous fracture of their thigh bone, which is really unfortunate for the field because that's-- you take the medicine to prevent the fracture, and here's the medication looking like it's causing the fracture, which in some people it does.
51:13
So, so that caused, um, a lot of people not to take the medicine.
51:18
Um, there was also earlier in the-- I'd say around two thousand five or six, uh, there were reports of what they call osteonecrosis of the jaw, where people would then be on this drug and then have a tooth pulled, and then the pu- the bone in the jaw not healing, becoming what we call necrotic or dead tissue in the mouth, which does not sound fun, you know, at all.

41 MINS LATER

92:56
What's one thing you want to leave the listener with today from our conversation? If one thing was going to land.

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