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David Seiffge
Vascular neurologist; professor of clinical neurology at the University of Bern and head of the Stroke Unit at Inselspital Bern, specializing in stroke and anticoagulation research.
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Sep 30, 2026
Perspectives from a neurologist and a cardiologist on LAA closure vs DOAC for stroke prevention
0:54
9:26

Lorenz RäberHOST
Now, while the overall outcomes I think are known to the audience, the first question that I would like to address to you as a neurologist is how you see the results in terms of stroke prevention.
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1:16David SeiffgeGUEST
So it's really a pleasure to be here and as a neurologist to have the opportunity to discuss those results and those trials.
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1:23David SeiffgeGUEST
And of course, as a neurologist, I'm very much focused on stroke outcomes because these are the outcomes that matter for me and for my colleagues.
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1:34David SeiffgeGUEST
We see that there are two large randomized controlled trials coming out, giving a lot of evidence, actually.
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1:39David SeiffgeGUEST
and we see that overall the stroke rates in both trials were quite low which i think is a good sign because stroke rates are low and both trials reported ischemic stroke but also hemorrhagic stroke sometimes merging those different stroke types together which for a stroke neurologist is a bit complicated because these These events are not 100% comparable.
7 MINS LATER

Lorenz RäberHOST
So which patient group might be very attractive for a percutaneous LA occlusion in your perspective as a stroke neurologist?