So I'm going to hand over to David now to talk through the methods and the first part of the results.

Thank you, Levon, and thank you to Rob, Emma, and all of the CCR team for the opportunity to present.

After many years sitting in an armchair commenting on other people's trials, it really is a great honor to be able to stand up and talk about one of our own.

We followed a pre-specified and pre-published protocol.

The population we were looking at was essentially all children in PICU excluding preterm neonates who were enrolled within 24 hours of both receiving invasive mechanical ventilation and either receiving or an intention to start feeding via the gastric route.

We had a number of exclusion criteria, so we excluded children receiving post-pyloric feeding or feeding via a jejunostomy, those with an end-of-life care plan in place, children who are on long-term invasive mechanical ventilation, and this is because they had no realistic prospect of meeting our primary endpoint of being free from invasive ventilation, those with a current or recent gut pathology or surgery, and those who are known to have been enrolled in the trial in the last six months.

Our intervention, as Laurent has said, is no routine GRV assessment to guide enteral feeding.

We had lots of discussion around that, didn't we? uh with the team but that's how we came up with that 12 hours and it seemed a reasonable pragmatic solution and it seemed like a reasonable thing to do 12 hours seemed reasonable so um we did involve people as i say that's all i can say it's a difficult question though to ask and people find it really difficult to answer even really senior clinicians