This activity is supported by an educational grant from Blueprint Medicines.

My name is Daniel D'Angelo.

I'm Chief of the Division of Leukemia at Dana-Farber Cancer Institute in Boston.

The goal of this program is to convert the growing body of TKI clinical data into practical guidance for everyday clinical use.

Let's begin by reviewing the physical and psychosocial burden of patients with indolent systemic mastocytosis.

When mast cells degranulate, they can release a lot of cytokines, histamine, interleukins, TNF, tryptase, that cause a wide range of systemic manifestations, including cardiovascular problems, hypotension, resulting sometimes in syncope or lightheadedness, tachycardia.

They can manifest in cutaneous issues such as flushing, pruritus, uticaria or hives, angioedema, gastrointestinal problems, including gastrointestinal abdominal cramping, diarrhea, sometimes esophageal reflux, leading to nausea, vomiting.

This session will now provide practical

This activity is supported by an educational grant from Blueprint Medicines.

My name is Daniel D'Angelo.

I'm Chief of the Division of Leukemia at Dana-Farber Cancer Institute in Boston.

The goal of this program is to convert the growing body of TKI clinical data into practical guidance for everyday clinical use.

Let's begin by reviewing the physical and psychosocial burden of patients with indolent systemic mastocytosis.

When mast cells degranulate, they can release a lot of cytokines, histamine, interleukins, TNF, tryptase, that cause a wide range of systemic manifestations, including cardiovascular problems, hypotension, resulting sometimes in syncope or lightheadedness, tachycardia.

They can manifest in cutaneous issues such as flushing, pruritus, uticaria or hives, angioedema, gastrointestinal problems, including gastrointestinal abdominal cramping, diarrhea, sometimes esophageal reflux, leading to nausea, vomiting.

This session will now provide practical