Um, so Dana, if you see someone with ulcerative proctitis with mild to moderate disease, um, how do you approach their treatment?

So, um, first we want to, uh, risk assess that patient, right? So what is the- ...

colonoscopy look like or flex sig look like.

Um, first, first of all, what is the visible extent? Um, and we think of, you know, formal definitions of proctitis now being around 15 centimeters or less, uh, with more extensive disease proximally.

We're doing biopsies not only in, in the visibly inflamed segment, but also the adjacent segment because I like to understand is there microscopic disease, uh, more proximal, in which case I'm gonna treat that patient more like a left-sided ulcerative, uh, colitis patient.

Um, remember that your suppositories will, will have a penetration of about five to 10 centimeters.

Um, and so that might not hit all patients with, um, you know, more proximal proctitis.

How do you survey these patients for colorectal cancer or dysplasia?