Let's take a look at some of the newest research published in JAMA this week and presented at the European Society of Intensive Care Medicine, ESICM, meeting that just took place in Lisbon, Portugal.

Well, Kirsten, let's kick things off with a question that intensivists deal with every day.

Where are all the fluids really coming from in patients that are ventilated in the ICU? In the PROFLUID study, Dr.

Block and colleagues conducted a prospective international cohort study in two hundred and six ICUs in forty-one countries on six continents, and analyzed two thousand four hundred and fifty-four adults who were mechanically ventilated early in their ICU stay.

The primary outcomes were the type and amount of fluid administered to patients.

The authors report that the daily fluid input peaked at three liters on day one of intubation, and fluid balance was close to neutral by day three.

What really stood out to me was that resuscitation fluid made up only sixteen percent of the total volume.

We have a study by Dr. Pelton and colleagues who explored the question, when should vasopressin be added in the setting of septic shock?