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Christopher Kramer

Christopher Kramer

Chief of the Cardiovascular Division at UVA Health and Immediate Past President of the American College of Cardiology

Aug 3, 2026

9:51
What was the main things that you wanted to find?
9:54
Yeah, so a little bit of background.
9:58
The SUMMIT trial followed the STEP-HEF-PEF trial.
10:02
So there was a secondary analysis of many of the diabetes studies that showed there was reduced heart failure events.
10:11
in diabetics with HFPEF.
10:13
And then the STEP HFPEF trial was a study of semaglutide in heart failure with preserved ejection fraction, or HFPEF.
10:26
And what the STEP HFPEF studies showed was, and the primary endpoint was exercise capacity and how patients felt as measured by the Kansas City Heart Failure Questionnaire, or KCCQ.

7 MINS LATER

17:47
But of course, from what you've told us so far, it seems to be more on effects, well, on fat pads around the

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