
Christina Megli
Assistant Professor of Obstetrics, Gynecology and Reproductive Sciences at University of Pittsburgh and maternal-fetal medicine specialist at UPMC Magee-Womens Hospital
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OCT 5
Jul 29, 2026
Dr. Christina Megli on the New Discovery of Macrophage Cells in the Amniotic Sac
9:19
9:26
9:33
9:39
9:49
A
8:53Alessia PlouhiHOST
So were you trying to simulate kind of a, you know, a pregnancy that was facing an infection there? And, and so is it, what, what infections might these guys be helpful during? And also what, Is it possible that they would be helpful during inflammatory events that are not infection related? I know there's a distinction there.

Christina MegliGUEST
So I'm going to describe a little bit the model that we use because I think it will help describe it a little bit.

Christina MegliGUEST
So we get tissue from C-sections in the absence of labor or in the absence of inflammation.

Christina MegliGUEST
And so what we do is we will cut up those pieces of the fetal membrane and we stick it in a little dish.

Christina MegliGUEST
And this dish is called... is interesting because it separates out the top part and then the bottom part.

Christina MegliGUEST
And so we put the fetal membrane on this dish and then we put bacteria and I'll talk a little bit about the bacteria that we that we are interested in that I think the membranes are important to defending it.
A
12:43Alessia PlouhiHOST
So talk to me about some of the, what we're thinking or what your hypothesis is about the strength of the amnion itself, maybe coupled with these soldiers that are macrophages or what role do each of them, may each of them have in stopping this, in offering a good defense and stopping the invading army?