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Brigham Buhler

Brigham Buhler

Oct 1, 2026

32:59
Yeah.
32:59
And I just had the privilege of testifying three weeks ago at the FDA on peptides in front of a committee of clinicians, of patient care advocates that were able to decide for themselves based off the data.
33:15
And what happened there was very, very disheartening.
33:19
Um, we provided the FDA with over 800 studies, over 5,000 pages of documents, including a retrospective analysis of BPC-157, where we looked at 14 million patients, and there were three adverse events.
33:34
Three.
33:35
And I can tell you, the FDA deemed all three of those as extr- as, uh, what was the verbiage they used? Uh, not extreme.
33:41
It was a major adverse event.
35:06
Yeah.
28:07
if it came
28:08
into contact with a cancer cell and took on a cancer phenotype and then exasperated that? And now we put trillions of these cells in your body And so fascinating.
28:18
2014, this is another woman, one of the leading scientists in stem cell research.
28:22
2014, she discovered this cell.
28:25
It is a, MUSE stands for multi-lineage stress enduring, which basically means traditional stem cells, you have to, negative 80 degrees or more.
28:36
And the second you thaw them out, they begin to die.
28:39
And so you've got to get them into the body quickly.

48 MINS LATER

76:24
This
16:00
So welcome, Brigham.
16:02
Thank you, Tony.
16:03
And thank you everyone for your time today.
16:05
For anyone living under a rock, man, we had a monumental win over at the FDA about three weeks ago.
16:14
They brought in a panel of medical professionals to review the FDA stance on peptides.
16:20
And those medical professionals, when presented with the data and the proper amount of time and resources to review that data, overturned six out of seven peptides that the FDA had wrongfully put on a banned list.
16:34
And I know intimately about this because during the Biden administration, I had submitted multiple FOIA requests to the FDA requesting clarification on why these peptides would be banned.
73:52
What's going on?
73:53
No, thank you.
73:54
That's a good question.
73:55
So, um, uh, I've been trying to ring the bell on this since it started.
73:58
Uh, during the Biden administration, the FDA, kind of in a vacuum, blindsided the public by putting peptides on the naughty list and said these 17 peptides are now considered dangerous to compound.
74:10
Um, meaning overnight, the regulatory landscape shifted, and so compounding pharmacies like mine legally could not make a safe product that had been in the market oftentimes for more than five, six years.
74:22
Um, and with no heads-up.

10 MINS LATER

84:19
Who gets to decide how much risk people should be able to take with their bodies? Like, should the FDA protect people from making bad medical decisions? Or, like, at what point, basically, how much evidence should be required before adults can access experimental treatment?
ZubyHOST
2:41
you have fantastic people working there.
2:43
Thank you.
2:44
We're trying to make it, healthcare should be fun.
2:46
Like one of the things I talk about is, you know, the broken system in America, at least, it's very regimented and uptight and everything's about how do we bill you and how do we, you know, get your insurance to pay for this or pay for that.
3:00
And the beauty of like pivoting away from that broken system and rolling into a cash pay model is the world is our oyster.
3:07
I was literally explaining to a high-level pro athlete today who was like, hey, man, why did my primary care never do this cancer screening? And it's nuanced.
3:17
And I don't know how it is overseas, but here in the U.S., every single test, every single medication, every single thing your doctor does has to be approved and controlled by the insurance companies.

54 MINS LATER

ZubyHOST
57:03
But what is the number one health issue facing the USA, in your opinion?
44:18
Wow.
44:18
Of pre-2019 cells, and that's important because so many of the various geneticists and folks from all different life that I have talked to have said, "Forget whether it's long COVID or vaccine-related injury or whatever it is, those elements can be transported through these various delivery mechanisms." And so my thought was why not take that risk profile out? Then you've got the risk of people having the allergic reaction or an immune response to somebody else's blood.
44:49
That I think is at like around twenty percent of people have an issue.
44:53
What if we use albumin, which is known, it's safe, it, it provides all of the essentials, but then we stack on healthy, young, vibrant stem cells that have never been vaccinated, that have never been, you know, that are prior to the whole-
49:29
Yeah
49:29
... d-d-does want a Muse cell.
49:31
Uh, and even that story's fascinating.
49:33
But the second part of that is, so multi-lineage, they can become anything.
92:09
It's a real problem
92:10
... where, where one of the things that he's enlightened me on, because I, I'm not a geneticist.
92:14
I don't know anything about that world.
92:16
He's like-Dude, if you do a gene sequencing test on a guy like Gordon Ryan, maybe there's a gene that's causing him to have these stomach issues.
92:24
So we run the full gene sequencing on Gordon at Ways to Well, and it comes back and, you know, offhand, I remember there's a couple of really interesting stuff.
92:33
Gordon has a gene that is like one in 10 million that makes your tendons, uh, more dense and more resilient.
92:43
So stronger, more rigid tendons that are able to res- are more resilient to damage.

15 MINS LATER

108:09
Sure
110:32
Yeah.
110:32
She's awesome, and she's a client and she's become a friend, and one day I was just telling her about all the crazy things going on around peptides.
110:39
This was, like, two years ago.
110:41
And she looks at me and she goes, "Brigham, you're gonna have to get political." And I was just thinking I don't ever wanna get political, and I don't even know how to get political and this is where I go back to the- how we started, that Steve Jobs quote, "When you look back at your life and you connect the dots, you'll realize you were always exactly where you were supposed to be." Hmm.
111:01
A week later, I get a phone call from Bobby Kennedy's team and they said, "Hey, Secretary Kennedy heard your podcast with Rogan.
111:09
Um, we want you to f- to fly out or come out.
111:12
We're gonna be in Dallas.

30 MINS LATER

141:22
Is this what that one guy Brian Johnson was doing?
Nick DiazSOUNDBITE_SPEAKER
16:41
(laughs) Yes.
16:41
There are over 150 peptides that big pharma is attempting to patent right now, because the future of medicine is peptides, and here's why.
16:51
Uh, we don't- we aren't compounding a drug.
16:54
We're taking something found naturally in nature, a signaling cell found in your body, just like stem cells, just like amnion, just like all of these crucial building blocks to our health and longevity, that are deficient in our foods, deficient in our diet, deficient in our lifestyle.
17:10
We don't get enough sun, we have too much screen time, we're inactive, and all of that shit's tanking in our bodies.
17:17
Shocker, right? And as we age, the- there's a precipitous decline in peptides, in building blocks.
17:24
One example, GHK, copper peptide.

5 MINS LATER

22:54
(exhales)
10:25
But I'm really excited about the future of peptides because in our practice, uh, you know, we use BPC-157- Mm-hmm.
10:32
... uh, TB 5000, uh, thymosin alpha, which was also pulled.
10:37
And you can get nutritional grade versions of these, but getting a good pharmaceutical compounded, highly sourced, you know, peptide where you know stability, sterility, potency and, and, and you have some, uh, belief in the efficacy because it was, it was compounded effectively.
10:57
The thought that we could just bring that back and make it available en masse, to me, is really exciting because we saw thousands of patients benefit from these-

7 MINS LATER

17:49
I mean, I'm, I'm much easier convinced that I can enhance my body's ability to heal itself at an accelerated rate than that I can take something that my body doesn't recognize, that you can't find in nature, that is not found anywhere on the surface of the Earth, somehow stick it in, and magically it's going to cause us to heal.
18:09
And if you...
18:10
Th- this is how you know that what you're saying is spot on.
18:14
While in one breath the FDA makes this decision in a vacuum to essentially ban and shut down accessibility to dozens of peptides-At the same time, Merck and several of the big pharmaceutical companies are attempting to patent over 200 different peptides.
7:40
What... I thought that there was supposed to be caps on insurance company profits. Is that not the case?
7:45
I'm unaware of any caps. The way, the way that this is structured is, so, PBMs were established in the '80s, and the, the premise was this. The federal government here in the United States, as capitalistic as we are, realized we had a problem, and they said, "Look, these insurance company, or these, uh, pharmaceutical companies are out of control. Their profit margins are through the roof. We've gotta make..."... medications affordable for the average American consumer and patient. We're going to establish these pharmacy benefit managers that will go out and negotiate on behalf of companies, corporations, and the little man, and they will fight for us to drive down the po- cost of healthcare. And so, they did. For a period of time, they went out and they negotiated with big pharma and they got big corporations and companies together to lobby and put together our buying power to drive down the cost of a prescription drug, making it affordable f- you know, for grandma and grandpa. Those were captured in the late '80s by the insurance companies. And so, what you saw, and one prime example I use all the time, is insulin. Why does Eli Lilly make the same exact profit margin on insulin almost 30 years later, but the price of insulin has four X'd? Where's the money going? It's like, where's the money, Lebowski? (laughs) Where's the money? And when you peel back the layers to the onion and you look, the money is going to the insurance companies. And so, it's a little tricky to explain, so I'll walk you through this as- as seamlessly as I can. Insurance companies say, "Hey, there's these middlemen, let's go buy them." They bought the middlemen. At that point, they controlled the negotiations with the pharmaceutical companies, and rather than negotiating down the price of the drugs, they said, "Aha! What if we negotiate up the price of the drugs via rebates and what we would call kickbacks in any other industry?" So, they negotiated rebates on almost every major pharmaceutical product. And if you want to be on UnitedHealthcare's plan, you gotta pay to play. If you wanna be on Medicare/Medicaid, that is all an illusion. Medicare and Medicaid are outsourced to who? The big five insurance companies. And so, throughout the chain and- of checks and balances in the system, they are now monetizing chronic disease, they're incentivized for you to be on more and more medications because it's a profit center for them. And so, to explain how that works, people go, "Well, wait a second. Why would an insurance company mark it up 'cause they're the ones paying for it?" Bullshit. They don't pay for it. Insurance companies pass that bill on at the end of the year to your employer, and 92% of people's insurance are from their employer. So, most people never realize. And then, there's- they also have what's called gap pricing. So, I on- the only reason I know all this, just to take people a walkthrough, like, history on me, is, I had the touch points. I was a drug rep and I went from that. I- I sold, you know, I launched Cialis in North America, the Viagra competitor, which was a blast. Like, it was fun, everyone loved it. Nobody was complaining about Cialis. But then I got pivoted to antidepressants and antipsychotics, and I saw the dark side of big pharma. And within eight months, I was out of there and I left to go be a device rep, where I stood in surgeries with the best and brightest surgeons in the world, and I saw those problems. And then from there, I became a serial entrepreneur in healthcare, where I attempted to work within the insurance framework, and what I saw was so eyeopening, it made it all finally make sense. I was like, "Oh, my God. This is what they're doing." And once you know the magic trick, you can see it over and over and over again. And so, the magic trick is, we push people to medications and prescription drugs. A real-world example would be the opioid crisis. What nobody realized, and an article came out maybe two months ago, I think in the New York Times, 30% of the money and revenue generated from opioid abuse in this country went to the big insurance companies. Never did they get indicted, never did they get questioned, never did they get sued. They skated scot-free, but they had negotiated rebates on opioids. Why that's important, is I owned pharmacies that offered alternatives to opioids. I would go out and educate clinicians on the importance of not prescribing opioids, because I lost my brother to opioids. They pushed it into the market, they let big pharma ramrod it via a deal with the FDA. The head of the FDA then went to go work for Purdue Pharma, who brought that drug to market, for a big huge fat salary three years later. Purdue Pharma, who created the Valium crisis in the '70s, then perpetuated the opioid crisis in the 2000s and the '90s, and then all of that was profiteered by big pharma and big insurance.

1 HR 2 MINS LATER

74:14
Copper IUD?
74:14
Yeah, and when women... No, a cop- not a copper IUD. This preceded all that. When an Essure procedure and when women were deciding to take these various things out, it absorbed into their uterus and they had to take out the whole uterus. People were having all sorts of side effects. There's a big class action lawsuit. Um, there were, uh, literally, like, surgical procedures I'm in at crucial points in heart surgeries even, where they're using high-def cameras, and when they would hit the ablation device, they never taste tested it with all the other equipment that's in the OR. So, you're at a crucial part of a heart surgery, you go hit an ablation device to burn or cauterize a piece of a heart tissue or whatever and piece of anatomy you're working on, the fucking camera would turn off. So imagine it's like a video game. You're doing the surgery looking at the camera because it blows it up in high res, and when you go to do a crucial part of the surgery, blackout screen, 'cause they had never tested the camera to work with these pieces of equipment. I mean, there was a device that literally s- like, a suction device, and they didn't realize that... It didn't have a disclaimer not to use it to suck, like, uh, blood out of anatomy when you're in the middle of surgery, and it literally sucked out, like, pieces of an organ and killed people. I mean, there's so many examples. And then even more Wild West, I'll tell you the most crazy fucking story ever. I- I told this on Rogan, and people, I swear, hand to God, this is true. I was in a surgery at the Houston Zoo on an animal, on a, on a tiger or leopard, I don't remember, on a big cat, and I noticed the shaver, they... It's, it's a piece that they, a piece of equipment they use to go in and clean up tissue in a joint, and it had green tape on it, and it was labeled with green or red, I don't remember now. It was labeled with tape. And so I noticed it was a loaner so I look at the serial number just 'cause I'm like, "Oh, it's a loaner. I- I... It's wild. The Houston Zoo has this fricking loaner handpiece." Uh, and like a month later, I'm in a human surgery at a hospital and I see the guy shaving with this shaver with a green piece of tape on it, and so at the end of the surgery, I wait for it to all be done and I put on some gloves and I look and it's the same fricking piece of equipment, the same exact handpiece that was in a veterinary surgical procedure. Okay, reps carry what are called trunk stock, right? When I was a surgical rep, I have, like, a million dollars in surgical equipment in my fucking trunk. And like, you have restrictions, like it's supposed to be kept at climate controlled temperatures, 85 degrees. You know, we can't guarantee there's not bacteria if you, the hospital... How in the hell is a rep supposed to drive an hour across town, carry that equipment in their trunk, put it into a surgical procedure, wash it, clean it, take it off, drive it to another hospital, and the whole time it's sitting in a trunk that's literally 150 fucking degrees? There's so many... I- people are just unaware that it's not what it is portrayed to be. The environment is not as safe as it's portrayed to be. Trust but verify. Do your research. Do your homework. Don't take surgery lightly. Know that everything is a calculated risk. And that's why I'm such an advocate for, like, preventative proactive care, getting predictive, prevent chronic disease. If you wanna stop the five chronic diseases that are killing people and running up healthcare and causing bankruptcy, let's start with not letting them fucking develop in the first place. Like-

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