Tell us about new ideas of the pathogenesis of Alzheimer's that this thing could actually work.

Well, in terms of new ideas about the pathogenesis of Alzheimer's, it's becoming pretty well recognized that there are a number of different secondary processes that really drive the disease forward, particularly at the stages where people start to have symptoms.

And some of those processes are things like narrow inflammation.

Another one is decreased neurogenesis in a region of the brain called the hippocampus.

Hippocampus is really important for learning and memory and emotional, assigning an emotional value to the things that we learn and for navigating our day-to-day experiences over the course of our lifetime.

And Sandy's work had shown that inhibiting this enzyme helped support the health of stem cells in the colon.

And that was what made us wonder, well, what if this could also help support stem cells in the brain? And the hippocampus is one of the few regions of the brain that makes new cells from stem cells that reside.

Tell us about this exciting finding of really the first pathway that shows that you can actually reverse the disease.