
Andrew Mihalache
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Sep 10, 2026
Fuchs Endothelial Corneal Dystrophy and Cardiometabolic Comorbidities
3:50
4:11
4:18
4:31
4:48

Andrew MihalacheGUEST
So for this study, we used the All of Us research program, which is this large, diverse cohort in the United States with over 300,000 participants, and using this data set, we were able to identify about 550 people who are diagnosed with Fuchs dystrophy, and then we matched them to about 5,500 controls who didn't have the condition.

Andrew MihalacheGUEST
And the idea behind this matching process was that we wanted to have two groups that were very similar and very comparable to each other.

Andrew MihalacheGUEST
So we made sure that these two groups were almost identical with respect to things like age, sex, race, ethnicity, uh, smoking and alcohol use, BMI, and other social determinants of health.

Andrew MihalacheGUEST
And then once we had these two comparable groups, we then asked ourselves, "Do patients with Fuchs have a greater prevalence of different cardiometabolic conditions compared to that similar control group?" And what we found was that people with Fuchs actually had a greater prevalence of some common conditions.

Andrew MihalacheGUEST
So for example, they were more likely to have diagnoses of type 2 diabetes, hypertension, high cholesterol levels, cerebrovascular disease, as well as obesity.
