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Andrei Seluanov

Andrei Seluanov

Researcher

Sep 21, 2026

12:23
But as a listener, can you maybe unpack why it's not that simple?
12:28
Because for human treatment, we don't do the gene therapy.
12:32
You know, it's a very difficult procedure because you need to introduce the gene to every cell in our body.
12:38
And we are talking about billions of cells.
12:41
It's not efficient.
12:42
What we did in mice is just a proof of principle because we introduced the gene into the oocytes, fertilized zygote, actually.
12:50
And there, it's easy to manipulate because when you have single cells, you can manipulate the genome and the whole mice is growing.

8 MINS LATER

20:42
I
12:23
But as a listener, can you maybe unpack why it's not that simple?
12:28
Because for human treatment, we don't do the gene therapy.
12:32
You know, it's a very difficult procedure because you need to introduce the gene to every cell in our body.
12:38
And we are talking about billions of cells.
12:41
It's not efficient.
12:42
What we did in mice is just a proof of principle because we introduced the gene into the oocytes, fertilized zygotes, actually.
12:50
And there, it's easy to manipulate, because when you have single cells, you can manipulate the genome, and the whole mice is growing.

8 MINS LATER

20:42
I

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