So do we really think it's real? And I'm wondering if the fact that there are biomarkers for Alzheimer's, put it in kind of like a different mental space for people who are approaching this and sort of what the implications of that would be for these other conditions that don't necessarily have that easy-to-touch validity.

Yeah, you hit the nail on the head.

You see absence of biomarkers, which reflects an absence of a clear pathophysiological or biological explanation for these disorders.

That puts psychiatry, I want to pick my words here, in a kind of la-la land, where people think this is all made up.

A bunch of psychiatrists get into a room, decide what's a disease, what's not a disease.

and that is not correct.

I would respond by saying absence of clear-cut biomarkers doesn't mean these conditions don't have significant impact in the lives of patients.

Instead, they're part of a bigger picture.