
Ali Dudley
Dr. Alicia "Ali" Dudley, DVM, MS, DACVIM — board-certified small animal internal medicine specialist and veterinary specialist consultant at IDEXX Medical Consulting Services.
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Aug 20, 2026
From Smear to Solution-Integrating Automated Blood Morphology into Anemia Workups
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10:28Sylvia ConwayHOST
Um, and this is gonna be quite a long answer, I appreciate, but can you give us sort of an overview of if we find those in an anemic patient, what should we be doing for next steps? So if we take them one by one as you listed before, that would be great.

Ali DudleyGUEST
Um, so if we take our spherocytes, and I'm thinking about immune-mediated hemolytic anemia, in those cases, then I'm, I'm looking to say, "Is there a, some other secondary factor that points me to a definitive diagnosis of IMHA?" And that might be agglutination, it might be multiple other evidences of, of a hemolytic process, like bilirubin in the blood or urine, or hemoglobin in the blood or urine.

Ali DudleyGUEST
Um, the fragmentation cells, so the acanthocytes, schistocytes, keratocytes, those I am thinking, is there either something that is directly causing those red, normal red blood cells to fragment, and that could be things like DIC or neoplasias like hemangiosarcoma.

Ali DudleyGUEST
Um, but something f- where normal red blood cells that are otherwise perfectly healthy are traveling through blood vessels and getting chopped up and destroyed.
12 MINS LATER
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23:46Sylvia ConwayHOST
So is the analyzer capable of detecting, so not abnormal white cells as such, but things like bands? But is it also capable of detecting, say, neoplastic white cells? And if we're finding abnormal white cells in or an abnormal distribution of white cells in an anemic patient, what should that point us towards? What should we be looking for?