Fasting While Taking GLP-1s
GLP-1 users face a hidden muscle-loss risk
Aug 25, 2026 · 33 min · 14 segments
Conflicting fasting advice can make it difficult to know whether intermittent fasting is actually appropriate for you—and the answer is often more nuanced than a simple yes or no. Episode #272 🎙️…
Fasting's really gained a ton of popularity over the years, and when something gains a lot of popularity, then everybody wants to chime in and have a say on it, and suddenly everybody's an expert on it, whether they've done fasting themselves or not, or have helped people or not.
There's opinions left, right, and center, and it's often really confusing for a lot of people.
Can I do fasting? This person says, "No, I shouldn't." This person says, "Oh, yes, I can." Or, "My healthcare provider said, 'Oh, no,' like women shouldn't fast, but my best friend going through perimenopause just lost 30 pounds, and so I'm just really confused." So there's a handful of these themes that we keep seeing come up, and a lot of questions that come into our Fasting Method inbox.
One of them is women and fasting, like throughout the entire lifespan, adult lifespan of a woman, there's concerns and questions about appropriateness.
Individuals who are slender or skinny to the eye but have metabolic syndrome and aren't quite sure they can treat that metabolic syndrome with fasting, and would like to, but they don't weigh very much.
You hear all of the time, fasting, you should fast if you're stressed, and fasting raises cortisol, and this and that, but it's not so black and white.
And then fasting's gonna break down your muscle mass, or if you're actively trying to gain muscle mass or reverse a condition like osteoporosis, so improving lean mass like bone mass, you shouldn't fast.
And my answer is usually that if you're a healthier individual, I mean, you might be on blood pressure medication or diabetic medication, but overall, you know, if you're combating metabolic syndrome or inflammatory conditions, but are otherwise able to work, you're not on like full disability, for example, you know, or you're able to sort of keep up with your activities even if you're feeling run down, generally, you know, you can fast.
Your doctor or your healthcare provider has to give you medical clearance to fast.
So I thought in today's episode, since we're getting to that time of the year, like you said, Terri, a lot of people are feeling frustrated about the summer, know that the holidays are quickly approaching, and, you know, just wanna get control of their health.
Yeah, so I thought maybe we could talk about five buckets or categories that we see comes into our email box.
box.I love it, and I think it's also really relevant to other people who have been fasting for a while but need some kind of reminders of some of the purposes and thoughts around that.
Fasting's really gained a ton of popularity over the years, and when something gains a lot of popularity, then everybody wants to chime in and have a say on it, and suddenly everybody's an expert on it, whether they've done fasting themselves or not, or have helped people or not.
There's opinions left, right, and center, and it's often really confusing for a lot of people.
Can I do fasting? This person says, "No, I shouldn't." This person says, "Oh, yes, I can." Or, "My healthcare provider said, 'Oh, no,' like women shouldn't fast, but my best friend going through perimenopause just lost 30 pounds, and so I'm just really confused." So there's a handful of these themes that we keep seeing come up, and a lot of questions that come into our Fasting Method inbox.
One of them is women and fasting, like throughout the entire lifespan, adult lifespan of a woman, there's concerns and questions about appropriateness.
Individuals who are slender or skinny to the eye but have metabolic syndrome and aren't quite sure they can treat that metabolic syndrome with fasting, and would like to, but they don't weigh very much.
You hear all of the time, fasting, you should fast if you're stressed, and fasting raises cortisol, and this and that, but it's not so black and white.
And then fasting's gonna break down your muscle mass, or if you're actively trying to gain muscle mass or reverse a condition like osteoporosis, so improving lean mass like bone mass, you shouldn't fast.
And my answer is usually that if you're a healthier individual, I mean, you might be on blood pressure medication or diabetic medication, but overall, you know, if you're combating metabolic syndrome or inflammatory conditions, but are otherwise able to work, you're not on like full disability, for example, you know, or you're able to sort of keep up with your activities even if you're feeling run down, generally, you know, you can fast.
Your doctor or your healthcare provider has to give you medical clearance to fast.
So I thought in today's episode, since we're getting to that time of the year, like you said, Terri, a lot of people are feeling frustrated about the summer, know that the holidays are quickly approaching, and, you know, just wanna get control of their health.
Yeah, so I thought maybe we could talk about five buckets or categories that we see comes into our email box.
box.I love it, and I think it's also really relevant to other people who have been fasting for a while but need some kind of reminders of some of the purposes and thoughts around that.
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Fasting While Taking GLP-1s
GLP-1 users face a hidden muscle-loss risk
The Muscle-Loss Tradeoff
Weight loss medications may change what weight means
Thin Outside, Fat Inside
A small body can still conceal serious disease
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