Sage Clinical Medicine & Research
Sep 4, 2026 · 3 min · 3 segments
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261472742
So this comprehensive review describes advances in genetic discoveries for Arctic valve stenosis and mitral valve prolapse over the past decades.
And familial studies allowed the identification of a few rare monogenic forms of AS, most of which are associated with congenital bicuspid aortic valve.
Large-scale genome-wide association studies, so GYs, have mapped 268 independent risk loci for aortic stenosis.
The genetic variants identified implicate lipid metabolism, inflammation, blood pressure regulation, and calcification as important determinants.
Mitral valve prolapse, on the other end, is a feature of genetic syndromes, many of them involving TGF-beta signaling pathway.
Emerging polygenic risk cores achieve significant risk prediction for both disease, so for both aortic stenosis and mitral valve prolapse, representing promising tools for early identification of high-risk individuals before clinical manifestation of the valvular disease.
This is clearly a must-read review article, and it provides a roadmap for future research and clinical translation, emphasizing the urgent need for prospective trials, testing genetically-informed intervention, especially pharmacotherapeutic intervention, for valvular disease prevention and treatment.
So this comprehensive review describes advances in genetic discoveries for Arctic valve stenosis and mitral valve prolapse over the past decades.
And familial studies allowed the identification of a few rare monogenic forms of AS, most of which are associated with congenital bicuspid aortic valve.
Large-scale genome-wide association studies, so GYs, have mapped 268 independent risk loci for aortic stenosis.
The genetic variants identified implicate lipid metabolism, inflammation, blood pressure regulation, and calcification as important determinants.
Mitral valve prolapse, on the other end, is a feature of genetic syndromes, many of them involving TGF-beta signaling pathway.
Emerging polygenic risk cores achieve significant risk prediction for both disease, so for both aortic stenosis and mitral valve prolapse, representing promising tools for early identification of high-risk individuals before clinical manifestation of the valvular disease.
This is clearly a must-read review article, and it provides a roadmap for future research and clinical translation, emphasizing the urgent need for prospective trials, testing genetically-informed intervention, especially pharmacotherapeutic intervention, for valvular disease prevention and treatment.
The rest of this transcript — segmented and speaker-labeled, so you land on the exact moment something was said
Search every transcript — by keyword, by phrase, or by meaning, across every show Radar indexes
Trends — what is surging across podcasts, measured against its own baseline
Alerts — when a name you follow appears in a newly indexed episode
No account is needed to search Radar.