Sage Clinical Medicine & Research
Sep 4, 2026 · 2 min · 2 segments
Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826261468625
And so this state-of-the-art review article is focused on multi-omics landscape of arctic stenosis.
And this review applies a multi-omics framework to arctic stenosis, integrating genomic, transcriptomic, proteomic, and metabolomic evidence.
Recent landmark studies have expanded the known genetic architecture of aortic stenosis in depth, identifying now over 240 risk loci and establishing that the genetic architecture of AS is distinct from that of atherosclerosis, with LPA as the dominant risk locus.
Transcriptomics, particularly at the single-cell level, has revealed cellular heterogeneity within the valve, identifying pro-fibrocalcific cell population and pathogenic processes such as endothelial to mesenchymal transition, as well as a regulatory role for non-counting RNAs, including H19, in osteogenics programs.
The comprehensive molecular characterization has revolutionized our understanding of aortic stenosis, reframing it as an active, genetically-influenced disease and paving the way for the development of targeted pharmacotherapies and precision diagnostics.
This is definitely a must-read article if you want to have a fresh update on the proteomic framework applied to Arctic stenosis.
And I also draw your attention on another state-of-the-art review article by the same group of authors that we are publishing in the same issue of the journal on the genomic landscape of Arctic valve stenosis as well as mitral valve prolapse.
And so this state-of-the-art review article is focused on multi-omics landscape of arctic stenosis.
And this review applies a multi-omics framework to arctic stenosis, integrating genomic, transcriptomic, proteomic, and metabolomic evidence.
Recent landmark studies have expanded the known genetic architecture of aortic stenosis in depth, identifying now over 240 risk loci and establishing that the genetic architecture of AS is distinct from that of atherosclerosis, with LPA as the dominant risk locus.
Transcriptomics, particularly at the single-cell level, has revealed cellular heterogeneity within the valve, identifying pro-fibrocalcific cell population and pathogenic processes such as endothelial to mesenchymal transition, as well as a regulatory role for non-counting RNAs, including H19, in osteogenics programs.
The comprehensive molecular characterization has revolutionized our understanding of aortic stenosis, reframing it as an active, genetically-influenced disease and paving the way for the development of targeted pharmacotherapies and precision diagnostics.
This is definitely a must-read article if you want to have a fresh update on the proteomic framework applied to Arctic stenosis.
And I also draw your attention on another state-of-the-art review article by the same group of authors that we are publishing in the same issue of the journal on the genomic landscape of Arctic valve stenosis as well as mitral valve prolapse.
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