Naturopathic Beauty's Clear Skin Sessions
Sep 24, 2026 · 12 min · 7 segments
Accutane can feel like a miracle and a minefield at the same time. When someone tells you isotretinoin is “just for your skin,” that misses the point: it’s a high-dose vitamin A retinoid that…
Stacey ShillingtonHostSo the first thing I want you to understand is that Accutane is not a skin treatment and It's a whole body treatment that just happens to change your skin.
And your body has special receptors that are designed to respond to vitamin A.
So the way I like to explain it to my patients is to think of them like light switches.
When a retinoid connects with one of those receptors, it can switch genes on or off inside the cell.
They're found in all tissues throughout your body, your liver, your digestive tract, your eyes, your bones, your brains.
So when you take a high dose of vitamin A retinoid every single day for five or six months, it's not just visiting the oil glands in your skin.
And that's why the side effects list is so long and why it touches so many different systems.
In fact, your doctor has to order regular blood work because Accutane can raise your triglycerides, your cholesterol, and your liver enzymes.
Of course, it causes the dry eyes, and in some people, it affects night vision.
It causes joint pain, back pain, especially if you're active, and it carries official warnings about depression and mood changes.
So your prescriber is supposed to be monitoring your mood the entire time.
When a medication needs monthly blood work, monthly pregnancy tests, and mood checks, that tells you something.
So the first thing I want you to understand is that Accutane is not a skin treatment and It's a whole body treatment that just happens to change your skin.
And your body has special receptors that are designed to respond to vitamin A.
So the way I like to explain it to my patients is to think of them like light switches.
When a retinoid connects with one of those receptors, it can switch genes on or off inside the cell.
They're found in all tissues throughout your body, your liver, your digestive tract, your eyes, your bones, your brains.
So when you take a high dose of vitamin A retinoid every single day for five or six months, it's not just visiting the oil glands in your skin.
And that's why the side effects list is so long and why it touches so many different systems.
In fact, your doctor has to order regular blood work because Accutane can raise your triglycerides, your cholesterol, and your liver enzymes.
Of course, it causes the dry eyes, and in some people, it affects night vision.
It causes joint pain, back pain, especially if you're active, and it carries official warnings about depression and mood changes.
So your prescriber is supposed to be monitoring your mood the entire time.
When a medication needs monthly blood work, monthly pregnancy tests, and mood checks, that tells you something.
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