Longevity Optimization with Kayla Barnes-Lentz
Sep 3, 2026 · 1 hr 17 min · 13 segments
Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most…
Tania DempseyGuest
Kayla Barnes-LentzHost
Why do women have endometriosis and PMOS and migraines? Really what you need to do is look at that common link, which really to me is the mast cell.

They are trying to protect you from exposure to viruses, parasites, bacteria, toxins.

Did you learn anything about mast cells in medical school? No, you know, it's interesting.

I think I heard the term mast cell as it relates to allergy and very briefly, but definitely not in my training early on, which is crazy.

It is so common in women to have anxiety during puberty, during perimenopause.

The mast cell is the only cell in the body that actually makes heparin, which is fascinating, and it releases just minuscule amounts.

I had a patient, 18 years old, about to go to college, and really, really dysfunctional.

We started her on GLP-1, like tiny, tiny dosage, and apparently within 24 hours, her mother said she was out running three miles a day.
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