Health Topics – Johns Hopkins Medicine Podcasts
Jun 19, 2026 · 1 min · 3 segments
Making CAR-T cells from donor bone marrow already used to treat someone’s cancer helped rein in cancer recurrence, a new study shows. Kimmel Cancer Center director William Nelson at Johns Hopkins says…
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Elizabeth TracyThere are off-the-shelf CAR T-cell preparations that some companies are trying to create.
This one's interesting because it's tethered to the bone marrow transplantation.
This approach by selecting particular T-cells, engineering them in a particular way, putting them in, you didn't need as many.
They hung around and they didn't cause graft-versus-cells disease.
They were pretty deliberately directed against the cancer itself.
I think this is something that would be an adjunct to bone marrow transplantation.
It's less and less fraught these days than ever before, which is why it's becoming so extensively used to treat sickle cells.
Nelson says there has also been some progress in using the cells to treat solid tumors.
There are off-the-shelf CAR T-cell preparations that some companies are trying to create.
This one's interesting because it's tethered to the bone marrow transplantation.
This approach by selecting particular T-cells, engineering them in a particular way, putting them in, you didn't need as many.
They hung around and they didn't cause graft-versus-cells disease.
They were pretty deliberately directed against the cancer itself.
I think this is something that would be an adjunct to bone marrow transplantation.
It's less and less fraught these days than ever before, which is why it's becoming so extensively used to treat sickle cells.
Nelson says there has also been some progress in using the cells to treat solid tumors.
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