Health Topics – Johns Hopkins Medicine Podcasts
Jun 19, 2026 · 1 min · 3 segments
Specially engineered T cells, one component of immune cells in your body, are called CAR-T cells, and for several years now have been used to treat blood cancers and some other conditions, with some…
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Elizabeth Tracy
William NelsonGuest
CAR T cells, when they were originally introduced for treating HIV, one of the challenges was that when they were genetically engineered, this is to remove immune cells from the body by a process of phoresis, to genetically engineer them to go after a very specific target and then re-infuse them.
Current generation of them, they managed to get them to live long enough to have a fair amount of success.
Having said that, they haven't been that helpful at all treating most solid organ cancers.
Now new advances using CAR T-cells engineered from donors may further expand their clinical utility, Nelson says.
CAR T cells, when they were originally introduced for treating HIV, one of the challenges was that when they were genetically engineered, this is to remove immune cells from the body by a process of phoresis, to genetically engineer them to go after a very specific target and then re-infuse them.
Current generation of them, they managed to get them to live long enough to have a fair amount of success.
Having said that, they haven't been that helpful at all treating most solid organ cancers.
Now new advances using CAR T-cells engineered from donors may further expand their clinical utility, Nelson says.
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