Sep 27, 2026 · 26 min · 15 segments
Send us Fan Mail Berberine could quietly block tamoxifen and your immunotherapy meds. Here's the science, Part 2. #Berberine #Tamoxifen…
Jay ChaplinHost
It has good effects on the immune system and on how tumors respond to immunotherapy.


Because again, on paper, and I mean literally on paper, in the lab literature, berberine looks like it's doing all the right things again.

I want to be very accurate here because there is a real and growing pile of preclinical work.

Some of it is genuinely interesting, and the metabolic practitioners out there are making a big deal out of it.





In a mouse liver cancer model, berberine flipped the immune-suppressing, or M2, macrophages away from the dark side and brought in more CD8-positive killer T cells into the tumor.


It has good effects on the immune system and on how tumors respond to immunotherapy.


Because again, on paper, and I mean literally on paper, in the lab literature, berberine looks like it's doing all the right things again.

I want to be very accurate here because there is a real and growing pile of preclinical work.

Some of it is genuinely interesting, and the metabolic practitioners out there are making a big deal out of it.





In a mouse liver cancer model, berberine flipped the immune-suppressing, or M2, macrophages away from the dark side and brought in more CD8-positive killer T cells into the tumor.

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