Sep 20, 2026 · 19 min · 11 segments
Send us Fan Mail Berberine is everywhere online right now. Here's what it actually does to cancer cells (Pt. 1).#Berberine #BerberineCancer…
Jay ChaplinHost
Let me give you some of the actual data, because decent with proof really beats miraculous with flashy vibes every day of the week.


And it did all of this without increasing hypoglycemia or side effects like metformin or insulin would.

For something that's a plant compound that you can just get over the counter, that's a genuinely respectable showing.

It's roughly in the neighborhood of an older diabetes drug, which is exactly why people originally called it Nature's Metformin.

And that's a nickname that's actually closer to the truth than the newer nickname of Nature's Ozempic.

Another meta-analysis of 27 other trials, about 2,600 patients, showed improvements in total cholesterol, LDL, HDL, and blood pressure.

Although, and I appreciate the honesty here, the authors themselves basically added a footnote saying the benefit can be substantiated to a limited degree, because a lot of the underlying studies weren't exactly gold standard.

In a proper trial, berberine cut liver fat content by about 53% versus 36% for lifestyle changes alone.

Let me give you some of the actual data, because decent with proof really beats miraculous with flashy vibes every day of the week.


And it did all of this without increasing hypoglycemia or side effects like metformin or insulin would.

For something that's a plant compound that you can just get over the counter, that's a genuinely respectable showing.

It's roughly in the neighborhood of an older diabetes drug, which is exactly why people originally called it Nature's Metformin.

And that's a nickname that's actually closer to the truth than the newer nickname of Nature's Ozempic.

Another meta-analysis of 27 other trials, about 2,600 patients, showed improvements in total cholesterol, LDL, HDL, and blood pressure.

Although, and I appreciate the honesty here, the authors themselves basically added a footnote saying the benefit can be substantiated to a limited degree, because a lot of the underlying studies weren't exactly gold standard.

In a proper trial, berberine cut liver fat content by about 53% versus 36% for lifestyle changes alone.
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