Peptides: Evidence-Based Medicine vs. Social Media Hype

📱 Send Us a Text Message! We’d love to hear from you! Please include your name and email address so we can reply. Don’t worry — this won’t sign you up for our email list. We’ll only use your info to respond to your question. Endocrinologist Dr. Komal Patil-Sisodia defines peptides as short amino-acid chains (with examples like insulin) and notes that any package or claim stating “contains peptides” is meaningless without knowing which peptide, how it was tested, and what it's proven to do. She outlines the FDA approval pathway from preclinical work through Phase 1–3 trials and FDA review, then lists the FDA-approved peptides she prescribes for metabolic health (insulin analogs, GLP-1/GIP agents, glucagon, pramlintide), osteoporosis and calcium disorders (teriparatide, abaloparatide, palopegteriparatide, calcitonin), and reproductive/pituitary conditions (GnRH agonists, somatostatin analogs, vasopressin/desmopressin, cosyntropin, setmelanotide, bremelanotide). She contrasts these with trending “gray market” peptides (e.g., BPC-157, TB-500, GHK-Cu), noting most lack published peer-reviewed randomized human trials and are often sold as “research chemicals” without purity oversight. Her key filter: ask what high-quality human evidence supports a claim — emphasizing informed choices, doctor-guided decisions, and evidence over hype. **In This Episode** - What a peptide actually is — and why the word alone doesn't mean anything - The FDA's Phase 1–3 approval pathway, explained in plain language - The full list of FDA-approved peptides Dr. Patil-Sisodia prescribes, organized by condition - Why trending “gray market” peptides like BPC-157, TB-500, and GHK-Cu haven't cleared that same evidence bar - The backlash from a recent social post — and what it revealed about asking for sources - The one question to ask before trying any new treatment **Timestamps** 00:00 | Welcome to Clearly Hormonal 01:03 | Peptides Everywhere Now 01:51 | Peptides Explained Simply 02:47 | How FDA Approval Works 05:13 | Peptides I Prescribe 08:42 | Social Media Peptide Hype 10:43 | My Viral Post Backlash 12:53 | Spotting Real Evidence 13:46 | Final Takeaways and Wrap **Connect** - Practice: eastsidemm.com - Instagram & TikTok: @drpatilsisodia Thanks for listening. Find more info about Clearly Hormonal on the website or Instagram.