Aug 12, 2026 · 16 min · 9 segments
In this *AJNR* Podcast author interview, Dr. Francis Deng speaks with Dr. Caline Azzi about recent studies identifying imaging and clinical predictors of expansion in traumatic subdural, subarachnoid…
Caline AzziGuest
Francis DengHost
Would you say that the hemorrhage compartment is less important than the overall clinical and imaging phenotype?

The compartment still matters, but the broader phenotype appears more useful for risk stratification.

Across SDH, SAH, IPH, higher risk was consistently associated with features such as larger hemorrhage burden, multi-compartment injury, mass effect, coagulopathy, and a worse neurologic exam.

So I would be uncomfortable admitting repeating CT in a patient with a larger hemorrhage, like an initial larger hemorrhage, multi-compartment injury, midline shift or other some kind of mass effect, abnormal coagulation or a low declining glasgow coma scale, intravenous neurologic symptom development, skull fracture, intrametricular hemorrhage, hydrocephalus, or limited ability to monitor the patient would also favor a closer surveillance.

So it sounds like we can start formulating in our mind a scoring system or a decision tree of some sort.

And in your SAH paper, you and your coauthors proposed a practical algorithm for clinicians to determine imaging-related management.

So the algorithm combines the imaging and clinical features to stratify patients into a low, moderate, and high-risk groups.

Low-risk patients with isolated traumatic subarachnoid hemorrhages and a stable neurologic exam may only require observation.

Moderate-risk patients may benefit from an early repeat CT, while high-risk patients, such as those with a low GSS, midline shift, larger associated hemorrhages, or severe coagulopathy, those require closer imaging surveillance and neurosurgical evaluation.

Would you say that the hemorrhage compartment is less important than the overall clinical and imaging phenotype?

The compartment still matters, but the broader phenotype appears more useful for risk stratification.

Across SDH, SAH, IPH, higher risk was consistently associated with features such as larger hemorrhage burden, multi-compartment injury, mass effect, coagulopathy, and a worse neurologic exam.

So I would be uncomfortable admitting repeating CT in a patient with a larger hemorrhage, like an initial larger hemorrhage, multi-compartment injury, midline shift or other some kind of mass effect, abnormal coagulation or a low declining glasgow coma scale, intravenous neurologic symptom development, skull fracture, intrametricular hemorrhage, hydrocephalus, or limited ability to monitor the patient would also favor a closer surveillance.

So it sounds like we can start formulating in our mind a scoring system or a decision tree of some sort.

And in your SAH paper, you and your coauthors proposed a practical algorithm for clinicians to determine imaging-related management.

So the algorithm combines the imaging and clinical features to stratify patients into a low, moderate, and high-risk groups.

Low-risk patients with isolated traumatic subarachnoid hemorrhages and a stable neurologic exam may only require observation.

Moderate-risk patients may benefit from an early repeat CT, while high-risk patients, such as those with a low GSS, midline shift, larger associated hemorrhages, or severe coagulopathy, those require closer imaging surveillance and neurosurgical evaluation.
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