Yttrium-90

Um, it, so it is very difficult to even know what kind of, uh, accuracy we're getting across the field.

Um, but I wanna quickly highlight what's happened in Y90 microsphere, uh, uh, uh, treatments.

Um, so with Y90 microspheres, um- It's often treated like a nuclear medicine treatment because here we're working with microspheres, I think, that are 50 nanometers big.

So it's almost like a liquid when you have tens of millions of these small little spheres.

So that's often why it's treated within nuclear medicine.

But practically for what helps patients, I think we could accept instead of shooting for far and getting there, we should shoot for a step forward from where we are.

And with that, I think we could continue to develop simplified tools.

We could take the example from what worked in Y90.

Um, we did some, some radiations in there as well.

Some SBRT radiation and Y90 radiation.

Um, that was the most recent, um, Procedure we did leading up to my liver transplant was that Y90.

And that one kind of knocked me on my butt for sure.

I dropped in weight pretty considerably just with the accumulation of chemo and radiation over the last year leading up to the transplant.

Um, we did some, some radiations in there as well.

Some SBRT radiation and Y90 radiation.

Um, that was the most recent, um, Procedure we did leading up to my liver transplant was that Y90.

And that one kind of knocked me on my butt for sure.

I dropped in weight pretty considerably just with the accumulation of chemo and radiation over the last year leading up to the transplant.

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I think this is a hugely important Y90 study.

I think this, to Tyler's point, this has sort of put into publication what a lot of us have been seeing in our own practices.

And I think now hopefully kind of extends that experience to a broader audience and gives people more confidence to practice in this way as well.

These are real world numbers.

This should be very highly generalizable, right? We should be seeing very similar things around the country, around the world, assuming that Y90 is being used in this way.

And I think by Y90 being used in this way, I think this goes back to what Tyler was talking about with the personalized asymmetry and being intentional in the way that the dose is being administered and way that the patient is being treated and knowing that the dose absolutely matters.

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If you look at the surgeries, surgeries oftentimes, even though in many instances, in fact, if you look at the longitudinal data, surgical resection uh does not oftentimes contribute substantially substantively to overall survivorship right but it is phenomenal at immediately lowering tumor burden and now we have all these incredible techniques radio frequency ablation laser ablation thermal ablation cryoablation All these very elegant techniques.

Additionally, in interventional radiology, interventions like Y90 and LU177, which are targeted drip radiations, again, are very elegant in their effects insofar that you get a lot of on-target effect and very little off-target effect in comparison to field radiation.

A similar thing could be said with proton beam radiation, which is very, very precise.

You can set the depth of that beam.