Wolbachia

And it's also actually providing us with a great ecosystem service because they're helping keep our rodent numbers down.

I hope nobody comes up with some Wolbachia-like system where all to do with the rats will release more cobras.

I don't think that's necessary.

The population is probably quite well, it's quite sustainable.

After we do 28 days of doxycycline, 10 mg per kg, PROS, of course, BID.

And then we take a month-long wait period, which during that time, doxycycline, which of course eliminates Wolbachia, is there's further elimination of Wolbachia during that extra month.

So it is important.

Then we give one dose of melarsomine 30 days later give a second and third dose with during especially during melarsomine steroids being administered you are destroying bags of antigens so they're you know these worms and it's they're huge so there's going to be a lot of reactivity there and then at the beginning You also, if the animal is symptomatic, you will use steroids as well to minimize those symptoms.

So the monohydrate form tends to have less GI effects.

So that's another thing you can do.

Dr. Moore had mentioned the 10 milligrams per kilogram BID for 28 days because we have shown that clears Wolbachia best and also gets rid of the surface proteins the best.

But we also know lower doses are effective in reduction too.