Vascular endothelial growth factor

The same pathway targeted by drugs like sildenafil and one that also happens to keep platelets from clumping together and choking off the very vessels trying to deliver that blood.

The other level is VEGF, vascular endothelial growth factor.

which is a signal your body sends when it needs to physically construct new blood vessels rather than just widen the existing ones.

It's a process called angiogenesis.

So if the short-term picture looks reasonably clean, What's actually driving my caution? It comes down to this.

BPC-157's single greatest strength is also mechanistically its greatest liability.

The reason this peptide heals tendons and guts and even brain tissue is that it aggressively promotes angiogenesis, the growth of new blood vessels largely through upregulating VEGF.

Cancer runs on exactly the same fuel.

And underneath of insulin are all these other growth factors that, you know, all the pharmaceutical companies are trying to inhibit the receptor or inhibit the actual growth factor.

So the major one being VEGF, VEGF, vascular endothelial growth factor.

So a classical drug would be one called Avastin, but it causes a lot of harms in the body because it's obviously blocking it indiscriminately, and so you end up with a lot of problems.

So that's one growth factor.

Insulin is triggering up higher, along with all the other growth factors.

And insulin is the one that, it's only insulin.

This has been empirically shown that, you know, when you look at IGF-1, VEGF, all of these that have RAS proteins that would amplify their signals, that RAS protein has to be plugged into the inside of the cell membrane.

And it's only insulin that plugs it in.

You have an elevated CA125 and an ovarian mass.

going to be worried about a cancer so then we start to refer people to the gyne oncologist and these patients go down a path that's very anxiety provoking and often for nothing so i really don't encourage people to use ca125 but i think it can still be used in a research setting to try to identify patients who have the superficial endometriosis subtype personally i think biomarkers are not going to be so helpful in diagnosing deep endometriosis or ovarian because ultrasound can do that reliably and really what we need to do is introduce education and teaching for people to start doing those tests biomarkers are going to be useful for those who do not have very easily visible disease on scan but have symptoms and ca125 could be a potential player There's another one, VEGF, that has some hope.

And that's because endometriosis is connected to the development of new blood supply called angiogenesis.

And VEGF has a connection to that process.

So there's a couple that are hopeful, but none that are ready for prime time.

What about genetic tests? Are there any genes that...

So whether I'm doing three reps of a heavy weight or doing 30 reps of a blood flow restriction rate, the muscle growth is similar.

Now, the strength isn't, but the hypertrophy is, and that's because it upregulates VEGF and it upregulates vascularity because it-- you're teaching it how to be hypoxic.

So one of the mainstays of people with chronic illness that cannot exert themselves is blood flow restriction training.

The other is a type of dynamic heart rate feedback training.

DNA, PDRN, polydeoxyribonucleotide, PN, polynucleotide.

Both of these act through the denosine A2A receptor activation, and they have downstream effects with VEGF, with fibroblasts, collagen, MEDF as well.

And so like what they tend to do is help with different things that people are looking for

for anti-aging.