vascular dementia

It's about 60% of dementia is Alzheimer's.

The second most common type is vascular dementia.

And there's a lot of overlap.

And so what vascular dementia is, is it's blockage of the small vessels in your brain.

And so if the blood vessels in your brain get blocked, they cause little areas of lack of oxygen in those spots and they'll cause little mini strokes.

And that's really what vascular dementia is.

It's it's little mini strokes in the brain and it's progressive.

And so we know that these cardiovascular changes in the brain also contribute to Alzheimer's as well.

Damage that network over enough time and the brain can pay the price.

Vascular cognitive impairment is an umbrella term covering cognitive problems associated with cerebrovascular disease.

At the severe end of that spectrum is vascular dementia.

And this can involve obvious events like strokes, but also cerebral small vessel disease, chronic hypoperfusion, microinfarcts, white matter injury, and repeated vascular insults that accumulate over the years.

Vesigen, or KAD, is the short peptide made from lysine, glutamate, and aspartate that I covered in the previous episode.

The proposed concept is vascular bioregulation, particularly around endothelial biology and gene expression effects.

And this is exactly where vascular cognitive impairment makes Vesigen intellectually interesting.

If endothelial dysfunction is part of the upstream disease process, then a compound proposed to influence endothelial biology immediately catches your attention.