UK Biobank

So you need to measure that stuff for hundreds of thousands or millions of people.

And for obvious reasons, you take a biobank like the UK Biobank.

What do they want to do? What do they exist for to promote health? That's their mission.

And so, of course, their main thing is They want researchers to develop polygenic scores that help existing adults predict their own life trajectory.

Am I at high risk of whatever it is, prostate cancer, schizophrenia? If I am, maybe I'll intervene early.

Similarly, and for the first time in the last few years, for embryos, So I take it the UK Biobank is not going to want to predict like nose shape or whatever.

I mean, I could, my

earlier intervention would be an earlier nose job.

This landmark study aimed to determine whether osteosarcopenia, the concurrent loss of muscle mass, muscle function, and bone density independently predicts new-onset AF.

Analyzing over four hundred eighty thousand participants from the UK Biobank over an extended median follow-up of nearly fourteen years, the researchers found that osteosarcopenia was independently associated with a significant one point three three four increased risk of incident AF.

Interestingly, isolated sarcopenia lost statistical significance after multivariate adjustment, showing the dual impairment creates a synergistic risk.

Importantly, these findings were robustly replicated in an independent validation cohort from South Korea, the HPES cohort, where osteosarcopenia confirmed more than a two-fold increase in AF risk.

the huge shared database of health data.

So the UK biobank.

Yeah, it's

another way.

Hey, is drinking a definite no-no? Is drinking got benefits? Oh my God, we fight about this topic like we fight about protein, we fight about seed oil.

The famous UK Biobank has 340,924 participants that had adequate data to understand how often they drank alcohol, what kind of alcohol, what was the volume of alcohol, how frequently they drank it.

And then they were followed for 13.4 years.

During those 13 years, little over 22,000 people died, not quite 10%.

Association between statin therapy and dementia risk.

Evidence with coenzyme Q7-related analysis.

This is the famous UK biobank, in this case, 173,000 participants.

Another database called All of Us Research Program, 83,000.

We're talking about a large national database in the UK today.

We're talking about UK Biobank, right? Uh, no.

Stay tuned.

Welcome to MandoSpot, everyone.

But the vision goes well beyond building a database.

Our future health aims to transform medicine.

Today, we're joined by Raghib Ali, CEO and principal investigator of Our Future Health, to talk about this ambitious undertaking, how it differs from UK Biobank, what it could mean for the future of precision medicine.

Raghib is also a clinical research professor at the University of Cambridge in the Institution of Metabolic Sciences.

a number of rare variants.

If you go to UK Biobank and all of us, about a million people start looking at these genes and finding people who have heterozygous loss-of-function mutations and then looking at their body composition, there is an astonishing amount of genetic variation in genes that are expressed in adipose tissue, but they're extracellular, like collagen proteins and atoms and metalloproteinases.

And they look together as if they represent quite a bit of the variation in health or absence of health of adipose tissue.

So we're having to move, basically, trying to become extracellular membrane biologists and understand the ECM more.

But we also have somewhere between three and four of those petabytes are human clinical data.

And some of those are from sort of semi-public resources like national biobanks uk biobank all of us and such some of those are from specific partnerships with academic medical centers that have given us data that is specific to a particular disease biology so one that has been disclosed is for example our partnership with the morefields hospital in the uk that has one of the world's largest collections of OCT data which is a form of eye scans and it turns out that in those eye scans you can see eye disease but you can also see a lot of other diseases as well it's not for nothing that people say that the eye is the window to the soul it's also the window into your brain and as it happens other parts of your body as well and so we are interrogating those OCT images together with our partners in Moorfields Hospital to understand how disease biology manifests in those modalities.

And so those are brought together.

As I said, we don't print humans.

So I think that it's really important that both governments and these philanthropic organizations make an effort to create large resources that enable research to be performed, especially among organizations that are less well-endowed financially but have really, really smart people, such as academic institutions and smaller companies.

So this type of cellular resource is one important example, and I applaud the effort.

The other that I think is arguably even more critical is creating additional and richer human cohort data resources such as the UK Biobank, All of Us, and so on and so forth, These are few and precious.

And human data is one of those things that is really impossible for even a single company, even a very well-endowed pharma company to collect.

It's pretty transferable at the end of the day.

or just Biobank in general? Sorry.

The UK Biobank.

You have to jump through a lot of hoops to get access to that data.

And someone jumps through