Tuftsin

Intranasal peptide delivery is an attractive option because the nasal cavity provides potential access to the central nervous system through the olfactory and trigeminal pathways.

And this can allow some peptides to reach the central nervous system, associated tissues, while partially bypassing the blood-brain barrier rather than relying entirely on absorption into the bloodstream first.

So let's look into how this works.

So after a peptide is sprayed into the upper nasal cavity, it may follow several routes.

And then lastly, we have cellular transport mechanisms, where compounds can cross nasal epithelial barriers through extracellular pathways or processes such as transcytosis.

Now, let's look at why intranasal can be preferable.

So for central nervous system-oriented peptides, the main theoretical advantages are that it's non-invasive, so no injection is required.

It's potentially faster for central nervous system exposure because nose-to-brain pathways can provide relatively rapid access to central nervous system targets.

Both of those are Russian peptides, which are nasally bioavailable, actually better nasally than subcutaneous.

And the C-Link mimics an immune molecule called Tuftsin.

and has been shown to have antiviral capabilities as well as significant anxiolytic capabilities.

So for anyone who's anxious, that might be something to consider.