Trastuzumab
MedicationWikipedia
141
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61
EPISODES
52
PODCASTS
Search complete. 141 mentions across 61 episodes found for "Trastuzumab".
Nov 3, 2026
Rhonda VoskuhlGUEST
Yeah, he's a famous guy.
Rhonda VoskuhlGUEST
He invented Herceptin.
Rhonda VoskuhlGUEST
That's right.
Rhonda VoskuhlGUEST
And he's at UCLA, where I'm from, right? And so I said to Denny Slaman, I said, because we know you're alpha and beta, I know this isn't complicated, really.
Nic RussellGUEST
Yeah.
Kate LangbroekHOST
And then during your, another form of your, I guess, coping was once again, you embracing the outdoors and taking on these physical challenges, as well as your campaigning to get Herceptin widely available to New Zealand women without it costing them $100,000 a year because it was so effective in treating certain types of breast cancer.
Kate LangbroekHOST
Yeah.
Kate LangbroekHOST
So you were doing that lobbying as well.
33 MINS LATER
Nic RussellGUEST
I think that's the best way to approach it, really.
Kate LangbroekHOST
Nick Russell, your capacity to share yourself and to take a lemon and if not turn it into lemonade, to turn it into something for the greater good is really extraordinary.
Kate LangbroekHOST
The lives you have touched with the millions of dollars you've raised through Kenzie's gift and your work with the Herceptin and now your book, Bollocks.
Kate LangbroekHOST
It's been such an honour for you to share your story and the story of Kenzie with us.
Vikas DandekarGUEST
And you find amazing results.
Vikas DandekarGUEST
So, I mean, from mid-90s, we've seen the kind of Herceptin, which is a breast cancer drug, Trastuzumab.
Vikas DandekarGUEST
Now there have been like layers of improvement.
Vikas DandekarGUEST
And then we've seen massive drugs like the one which I can actually mention here is about Keytruda.
Kerre WoodhamHOST
What an awful, awful situation to be in and an awful, awful conundrum.
Kerre WoodhamHOST
What would you do? And perhaps what are the discussions that you've had within your family? Remember when Herceptin wasn't funded and that seemed to hit younger women particularly.
Kerre WoodhamHOST
That was a dreadful decision to have to make.
Kerre WoodhamHOST
And yet Herceptin had very good survival rates.
Kerre WoodhamHOST
So, you know, what do you do? I suppose it depends on your circumstances, your age and stage.
Kerre WoodhamHOST
If you're a parent with young children, I imagine you would fight.
Karen ReillyGUEST
it spreads rapidly and most people die within the first year.
Karen ReillyGUEST
But I was so fortunate because at the time, North Shore Hospital was only using this drug called Herceptin, which is a genetic marker that targets that particular type of cancer.
Karen ReillyGUEST
They were only using it with people who had metastatic disease where it's in your other organs, so your stage four.
Karen ReillyGUEST
I was stage 3B, which is One little stage before you go to stage four.
9 MINS LATER
Chris ReillyGUEST
No,
Andy StaibHOST
I would agree a thousand percent.
Andy StaibHOST
Karen, you referenced something called Herceptin.
speaker_1SOUNDBITE_SPEAKER
Mm-hmm.
Trevor GearHOST
And other things as well.
Trevor GearHOST
Major breast cancer drugs like Tamoxifen and Herceptin were developed through mouse research, leading to a massive decline in breast cancer mortality.
Trevor GearHOST
Immunotherapy, modern immune checkpoint inhibitors, which train the human immune system to fight off advanced tumors, were designed and perfected using lab animals.
Trevor GearHOST
And other things, organ transplants, we talked last week, I think, about uh heart transplants all of the medications to help the body accept and not reject the new organ have been tested through through animals as well things like cardiac pacemakers replacement heart valves heavily relied on on animal testing so right at the outset cuz you said yes you don't you think animal testing is a justifiable thing so presumably it's difficult to put yourself on the other side of that.
Savannah CaldwellGUEST
Then we would have to do chemo for as long as I could handle it, as long as my body can handle it.
Savannah CaldwellGUEST
And then I'll be on treatment for the rest of my life with Herceptin and Progetta.
Savannah CaldwellGUEST
And then I do a bone infusion to strengthen the bones that were eaten by the cancer.
Savannah CaldwellGUEST
But even that, all of this has side effects, insane side effects.
14 MINS LATER
Nick CaldwellGUEST
Okay.
Nick CaldwellGUEST
Yeah.
Nick CaldwellGUEST
And then she was already taking Herceptin and Progetta, which is the hormone or the targeted therapies.
Nick CaldwellGUEST
And she's continued with that since the beginning of treatment.
Eve PlumbGUEST
And there's so many drugs that have been developed.
Eve PlumbGUEST
There was one that I used called Herceptin that was specifically for my type of breast cancer.
Eila MellHOST
Yeah.
Eila MellHOST
Right.
Noor AbouhadraGUEST
However, no one's actually looked at this question yet in kind of a dedicated specific way to say, if they're PD-L1 off the bat, I'm just going to continue immunotherapy in the background and change the backbone.
Noor AbouhadraGUEST
And I think it's an important question because if you look at the Herceptin story, that's what we do in HER2 positive.
Noor AbouhadraGUEST
Obviously things have changed a little within HER2, but you're constantly engaging the HER2 receptor with another backbone.
Noor AbouhadraGUEST
You're asking an unanswered question in triple negative breast cancer that some folks aren't starting to look into because It's important to know.
Fran ViscoGUEST
And as you say, move the needle.
Fran ViscoGUEST
And, you know, it has developed a number of innovative mechanisms and the work that DOD funding helped with Herceptin.
Fran ViscoGUEST
helped with the CDK inhibitors, helped in a number of different things that have made a difference in the lives of breast cancer patients.
Fran ViscoGUEST
But you're really limited by what the scientific community proposes.
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