Translational Psychiatry

Pain severity was a strong predictor of nocturnal and morning cravings and moderated the association between WASO and opioid use.

Our final article is in Translational Psychiatry and is titled White Matter Signatures of Addiction Diverge Across Opioids, Cannabis, and Nicotine and Predict Impulsive Choice in Cannabis Dependence.

This cross-sectional, dual-centered diffusion MRI study compared white matter microstructure in 87 individuals with cannabis, opioid, or nicotine dependence and 53 non-smoking healthy controls, examining associations with impulsive decision-making and substance use severity.

Cannabis and opioid dependence exhibited overlapping, widespread reductions in fractional anisotropy and increases in mean diffusivity and orientation dispersion across frontotemporal, parietal, and limbic pathways, whereas nicotine dependence showed more circumscribed alterations, primarily in mean diffusivity within anterior and callosal regions.

Ketamine therapy can reshape the brain.

A study published in Translational Psychiatry identified distinct, time-specific shifts in brain network communication following infusion, showing that ketamine temporarily opens neural floodgates to restore neuroplasticity and normalize hyperactive depression circuits.

Identifying these exact checkpoints enables drug developers to design antidepressants that deliver rapid relief without inducing dissociation.

And finally, does gravity influence our genome? Removing the constant pull of Earth's gravity offers molecular biologists an unprecedented window into how human cells manage, express, and protect their DNA.

Ketamine therapy can reshape the brain.

A study published in Translational Psychiatry identified distinct, time-specific shifts in brain network communication following infusion, showing that ketamine temporarily opens neural floodgates to restore neuroplasticity and normalize hyperactive depression circuits.

Identifying these exact checkpoints enables drug developers to design antidepressants that deliver rapid relief without inducing dissociation.

And finally, does gravity influence our genome? Removing the constant pull of Earth's gravity offers molecular biologists an unprecedented window into how human cells manage, express, and protect their DNA.

One of my favorite book series ever.

Last story, last week, people published in Translational Psychiatry.

Their work, transplanting gut microbiota from humans with schizophrenia into mice.

Uh-oh.

Part of that brain weakens.

And a study in the Translational Psychiatry found that people that have high stress levels have reduced ACC or internal conflict monitor function.

I don't know, do you remember-- I don't know how old you are, but do you remember an advert where they used to have, Duracell used to have these batteries, and they would have their competitor's batteries and their batteries and they put them into these bunnies.

And they showed that Duracell batteries last longer because the other bunnies lost their battery quite soon.