thrombotic thrombocytopenic purpura
DisorderWikipedia
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Search complete. 35 mentions across 5 episodes found for "thrombotic thrombocytopenic purpura".
Oct 26, 2026
CaleHOST
What does the bacon do other than...
Alison ChandlerGUEST
So looking at complement activation, particularly when you're sort of looking at conditions such as AHUS, which, of course, we don't have a test for, unlike TTP, which we do.
Alison ChandlerGUEST
So that was like I was very pleased to see that presentation.
Alison ChandlerGUEST
It was excellent and really informative.
Cathy Handy MarshallHOST
All CLL patients should be counseled on the use of sunscreen while outdoors and should undergo preventive screening examinations at least yearly.
Charlie WienerHOST
Before we close, TTP was also one of the options.
Charlie WienerHOST
Why did you not even consider that?
Cathy Handy MarshallHOST
TTP is not a typical complication of CLL, and again, the smear was important.
Cathy Handy MarshallHOST
Similar to DIC, you'll see schistocytes in TTP.
Cathy Handy MarshallHOST
We all should get used to looking at blood smears.
Cathy Handy MarshallHOST
It's an inexpensive and valuable test.
Rohit GosainHOST
patient.All right, moving along into the world of ITP.
Rohit GosainHOST
But before we get into the ITP management, [beep] Dr. Raj Dilaw from Arizona wants to know, how do you differentiate between ITP, atypical HUS, or TTP, especially when that patient is inpatient and while we are awaiting ADAMTS13? How are you managing these patients?
Ronak MistryGUEST
This is a really, really important question, something very, very fundamental, 'cause everything shows up with low platelets, right? So, you know, I mean, again, I think clinical history is super important here.
Ronak MistryGUEST
When you're trying to work up someone with ITP, typically they may be either asymptomatic or just present with mucocutaneous bleeding.
Ronak MistryGUEST
This is gonna be in contrast to patients with T- TTP or atypical HUS, most of whom, when you look at them, are much, much sicker.
Ronak MistryGUEST
TTP is gonna present with vague symptoms like headaches, abdominal pain, chest pain, shortness of breath.
Ronak MistryGUEST
Atypical HUS are gonna be very ill, and many will have a history of, of diarrheal issues, and just, like, overall feeling not well.
Ronak MistryGUEST
You should see that in ITP, it's likely just an isolated thrombocytopenia.
speaker_0HOST
At this point, we have identified a TMA syndrome, but we have not yet established its cause.
speaker_0HOST
That distinction is critical because the immediate treatment of TTP differs from that of complement-mediated AHUS.
speaker_0HOST
Step 2.
speaker_0HOST
Urgently distinguish TTP, sugar toxin associated HUS, and other TMAs.
speaker_0HOST
There are three major diagnostic categories to consider, thrombotic thrombocytopenic purpura, sugar toxin-associated hemolytic uremic syndrome, and complement-mediated TMA.
speaker_0HOST
First, thrombotic thrombocytopenic purpura, or TTP.
speaker_0HOST
TTP results from severe deficiency of ADAMTS13, the enzyme responsible for cleaving unusually large von Willebrand factor multimers.
speaker_0HOST
Without sufficient ADAMTS13 activity, platelet-rich microthrombi form in the microcirculation, producing thrombocytopenia, microangiopathic hemolytic anemia, and potentially life-threatening neurologic and cardiac injury.