Testosterone

This indicates that combining several physical characteristics did not provide a reliable indicator of biological aging in the study population.

Testosterone showed a similarly complex pattern.

Higher circulating levels were associated with greater fat-free mass, broader shoulders relative to the hips and lower waist-to-chest ratios.

Initial analyses also identified some associations between testosterone and inflammatory markers, generally suggesting lower inflammation at higher testosterone concentrations.

These relationships may be more relevant to aging-related physiology than facial proportions or physical features established during development.

Quote These associations most likely reflect the well-established relationship between adiposity, inflammation, and biological aging rather than the costs of developing sexually dimorphic traits." The study contributes to an ongoing debate about testosterone, reproductive investment, and healthy aging.

Although some evolutionary hypotheses predict biological costs from greater androgen-related development, Testosterone also supports muscle maintenance, physical performance, and metabolic function.

Its effects may therefore depend on age, body composition, health status, and other physiological factors.

I don't like ridiculously long esters.

I will not use Sustanon.

If he gave it to me for free and that's all I could get, I'd probably use it.

But I don't want to use it.

I've even had people say that they think Sustanon is short ester.

I'm

like, no.

No. I'd hire Hematocrit on Sustanon because it builds up further.

The cardiovascular disease question is a little bit more difficult, and the data are a little bit more muddled, but on balance, they come out in the direction of TRT does not increase the risk of cardiovascular disease.

Now, there was a big trial that was completed last year called the TRAVERSE trial that gave men Androgel, so topical testosterone, and followed them for, I wanna say, three or four years, And there was no increase in the incidence of ASCVD, atherosclerotic cardiovascular disease.

But there is, so at face value, that study was taken to mean, look, we have one more study, the biggest and best, that demonstrated no increase in the risk of cardiovascular disease with TRT.

So the debate should be settled once and for all.

So you're limited in the esters that you can choose.

So there's Sustanon, of course, is everywhere throughout the world.

And Undecanoate, essentially Nibido, are the two modalities that you see the most here.

And they're not dosed properly.

I had a client who was working with type two diabetic.

He lost close to 100 pounds and his testosterone doubled.

So in that case, like, oh, the deficit was it was terrible for his androgens.

Like, no, in that case, the deficit was necessary and it would it the it improved the overall metabolic function to the point that a testicular function could work appropriately and bring his testosterone up to a reasonable level so there's the starting context determines whether somebody needs to reverse course on their on the the diet and improve metabolic function versus actually move into the deficit so it's a case-by-case basis and basically what i do is i look at history context previous diets current labs and then make an assessment from there

And are there particular signs that someone would see showing that they're ready to actually start a diet?

The biggest things are going to be, there's some lab markers, but the previous history.

So what was your previous dietary intake or dietary setup? If you were in a deficit, how large was the deficit? If you were fasting, what was the fasting regimen? If you were doing keto, low-carb or carnivore, what was going on there? Do you need to bring your carbs on board and go through that transition first? Then the next piece is going to be, what is your current body state? Are you obese, type 2 diabetic, fatty liver? You really need to correct that quick.

Or are you somebody who's already very lean and is suffering more with metabolic issues, lower testosterone, changes in the menstrual cycle, thyroid hormone shot, etc.? So where are you falling in that spectrum? Then there's symptoms.

The cardiovascular disease question is a little bit more difficult, and the data are a little bit more muddled, but on balance, they come out in the direction of TRT does not increase the risk of cardiovascular disease.

Now, there's a big trial that was completed last year called the TRAVERSE trial that gave men Androgel, so topical testosterone, and followed them for, I wanna say, three or four years And there was no increase in the incidence of ASCVD, atherosclerotic cardiovascular disease.

But there is, so at face value, that study was taken to mean, look, we have one more study, the biggest and best, that demonstrated no increase in the risk of cardiovascular disease with TRT.

So the debate should be settled once and for all.

I'm Dr. Andy Galpin.

I'm a professor and scientist of human performance, and in today's episode, we're gonna be talking about all things testosterone and performance.

In the previous episode, I had my colleague and friend, Dr. Ben House, and we talked at length about all things testosterone and performance.

And I left that thinking we covered so much ground, but yet there's a few things that we either went through quickly or just didn't get the chance to touch upon, and I just wanted to come right back in the studio and complete that conversation.

So that's our goal today.

I learned a ton from Ben.

I learned a ton in the last several months preparing for this and, and going over the topic.

So that said, let's dive in and start talking about testosterone and performance.

Now let's start right at the top here with John.

"How long can, can I get away with using a test suspension injectable Androgel blend on weak body parts during your off season? Two times per week for 10 to 12 weeks?" I mean, uh, let your post-injection pain and liver enzyme increase, uh, tell you what to do.

So, you know, if you're going to use this, I would do blood work ideally every four weeks, but at the latest eight weeks.

And, you know, if you do it every four weeks, it's like three times...

Or four times before and three times during af- uh, during.

Right at week four, eight, and 12, and then you'll steadily see your liver enzymes increase and maybe your serum estradiol levels increase, which allows you to alter your DHT intake or increase your aromatase inhibitor intake.

And whether that's Aromasin or Arimidex, Letrozole, I don't think that's a good idea, or, or change the ratio between total test and Primo, right? Um, and, and the post-injection pain with test suspension or injectable Androgel is legit.

You can dilute it a little bit with injectable carnitine or maybe Pro Vigorous blend.