systemic lupus erythematosus

And we're excited about the upcoming potential for its use in lupus and in Sjogren's disease.

It had a successful phase two trial in lupus, which is not easy to accomplish.

Lupus is a difficult disease to show separation from placebo when you're trying a new mechanism.

And the fact that it did so well in phase two bodes well for phase three outcomes, which we are awaiting.

And they decided to use the drug in Sjogren's, so went straight into phase three with that disease as well.

Yeah.

I mean, the cool thing is a lot of the disease-modifying therapies for the diseases that we mentioned, rheumatoid arthritis, SLE, IBD, are mostly... targeting the cytokine with antibodies.

So basically to try and block the ability of the cytokine to bind to its receptor.

And so you have to maintain, since the cytokines are continuously being produced because of the chronic nature of the disease, you have to maintain those antibodies at a certain level.

Okay.

So If I were to improvise some sort of association, hypothyroidism, autoimmune disease, Hashimoto, you do need to know associated pathologies such as increased risk of lymphoma and autoimmune diseases in general, hypothyroidism, Hashimoto's associated, as well as increased risk of CNS lymphoma that we see with autoimmune diseases like SLE, Hashimoto.

So it's sort of just a generic throwaway answer choice, wrong fucking answer.

choice B, marginal and ulcer, wrong fucking answer.

But, yeah, you might consider that Jax might be an increased risk for cryptococcal infections.

Speaking of opportunistic infections, a Thai study looked at pediatric SLE patients.

You know, they have more severe disease, do they not? And they looked at 177 pediatric SLE, 38 develop an opportunistic infection, 38 out of 177.

My goodness, that's like a 16, 17% risk.

3.4 events per 100 patient years.

was never

Lupus.

Except for the one time it was Lupus.

But it was Lupus.

What a twist.

What else was I doing? At 21? I think I was playing Magic a

Wrong fucking answer.

This is one of the hereditary causes of SLE.

And NBME asks it.

It's the first time you're hearing it.

Sounds very weird.

I've talked about it in my clips before.

So you just need to know that SLE, the malar rash, the lupus nephritis, These pathologies are due to a type 3 hypersensitivity where you have immune complex deposition.

And immune complexes, IgM and IgG have complement binding sites at the FC regions.

Autoimmune disorders like ADEM, I'm not even going to try to pronounce all of the words in that Four-letter sequence.

Lupus, Sjogren's syndrome, something called MG that I cannot pronounce, sarcoidosis, Lyme disease, human T-cell lymphotropic virus 1, stroke, ALS, muscular dystrophy, hypothyroidism, hypertension, and many other diseases.

issues mimic that disease and add to the chaos.

Then this says to make matters even more complicated, MS looks very different between person to person and then within that can vary in the same person over