systemic inflammatory response syndrome

The first time I actually was exposed to this concept, I had no idea I was being exposed to this concept, was in 1998 when I was in, doing my intensive, doing my medical, sorry, doing my internal medicine, there we go, doing my internal medicine training in my third year of medical school, sorry, 2000, when I was doing my internal medicine training.

And we had this thing called systemic inflammatory response syndrome, SIRS, S-I-R-S.

And back then, we weren't quite sure what it was.

We knew what it responded to.

I have this neurological explosion and immune atomic bomb go off in my body.

I now have full-blown SIRS symptoms, MS-like symptoms.

I start losing my vision.

I start having twitches and tremors and muscle weakness all over my body.

I am one of the eye doctors here at New Sight Vision Therapy Clinic in Provo, Utah.

And we specialize in caring for the things that you can't fix with glasses and contacts.

That includes everything like we were just talking about with SIRS and long COVID and Epstein-Barr.

It includes concussion and post-concussion syndrome.

And it has a effect on microcirculation.

Obviously, this is classically used in SIRS.

And it's a part of the Shoemaker Protocol.

Once people are at a certain point of recovery, you know, the SIRS protocol involves nasal sprays of VIP to help regrow brain, to help restore gray matter, to help, you know, msh to help like restore the immune system from the damaging effects of of mold and chronic inflammatory response syndrome but i've recently seen some really interesting use cases of vip as almost like a nootropic like really small doses of that combined with like c-link or c-max And it seems to the microcirculation seems to have like a dopamine regulating effect and just like health people really lock in.

And actually, this was a client of mine that shared this this data point with me, like, gosh, it must be like five or six years ago now.

And he was using it and I was like, why do you love it so much? And he's an ADHD patient and he's been on Ritalin and he's on prescribed Adderall and all these things.

But through that whole process, it was fairly traumatic and we couldn't find a physician who could give us the right answers.

We also had legitimate diagnoses of SIRS, also MCAS, biotoxin illness, like all of these written down diagnoses for the four of us.

And every physician I advised still wasn't like, Considering the intricacies, we've been privileged to work with some clients together and you understand like there are legitimately some clients who have to take a sprinkle of a capsule to try a supplement.

And we were those people.

There's so many early warning systems.

There's MEWS, NEWS, SIRS, SIRS with lactate.

Epic has a deterioration model.

Tom actually published the JAMA paper on the Epic deterioration model.

So these are immunomodulating, anti-inflammatory, cell regenerative, calming anti-inflammatory peptides.

VIP, vasoactive intestinal peptide, could be great for people that have SIRS, chronic inflammatory res- response syndrome, which has a mast cell activation syndrome response component to it in many ways.

So p- and people that have mold toxicity and chronic Lyme can have SIRS, and we like VIP and KPV and BPC 57.

These different acronyms are peptides that have anti-inflammatory and immune regulating benefits, right? And that's not to say the people that have histamine intolerance shouldn't be cautious with it and be conservative.

Work with a qualified practitioner that knows peptides, like us.

work.Yeah, I think this is a really important question.

The Phoenix criteria is an important step forward because they move us away from the SIRS definition and toward what we really care about clinically, life-threatening organ dysfunction that's associated with an infection.

Uh, it also gives us a more standardized definition, which is really helpful for research and for comparing sepsis outcomes across different hospital systems and countries.

The challenge is applying this criteria to lower resource settings.

Septic shock carries a hospital mortality of around 40% or more.

The older concept of SIRS, Systemic Inflammatory Response Syndrome, is no longer used to define sepsis because many patients with SIRS don't have sepsis, and some with sepsis don't meet SIRS criteria.

For children, the newer Phoenix criteria have been introduced.

How do we recognize sepsis early in the emergency room?

I like literally reached out to so many.

I, I contacted my doctor friends who do chronic illness like Lyme and MCAS and SIRS and I-- like literally everyone that was in all these different fields and I said, "Can you try this and tell me what you find out?" And that was before I ever opened my mouth about it.

And so it kinda-- like I said, though, I got censored.

I got taken off Instagram in September of '24, right as it was catching on, and I wasn't really allowed to t-defend my stance.