sympathetic nervous system

And indeed, we know this because the activity of the hypothalamic AMP kinase is mediated by specific regulation of the sympathetic and indeed the parasympathetic nervous systems.

So the SNS and the PSNS.

Now, The fact that inhibition of the hypothalamic AMP kinase leads to anorexia in the murine model.

And with that, because of the brown adipose, increased thermogenesis and therefore elevated energy expenditure makes it an important target with its potential for controlling both sides of of a ratio and proportion, or if you want an axis of energy, bioenergetic balanced equation.

So we need to examine all those different cellular phenomena at the organ-based level, right? So adipose and skeletal muscle wasting are definitely associated with the central and the sympathetic nervous systems.

So when you think about the SNS, the sympathetic nervous system, what is it normally described at? Well, you know it's called sympathetic because it's the classical what? Fight or flight response.

because it's a direct readout of autonomic innervation of peripheral tissues.

Whereas the HPA axis, hypothalamic pituitary adrenal axis, mediates a systemic endocrine response via glucocorticoid release.

Because at least that's, we see the players already accumulating, right? So the central nervous system and the sympathetic nervous system are functioning directly.

together, which they always do.

But in this case, let's pronounce a little bit about the sympathetic nervous system, the SNS.

We already know the SNS, when it's functioning, promotes catabolism.

Okay.

So coming back to, I'm thinking about, so you talked about in our fight or flight nervous system, our sympathetic nervous system, the blood drains, we can't think that's going to affect executive functioning.

When you talked about earlier, you were talking about dopamine as far as, you know, being out in the sun, nature, singing at the top of your lungs, petting an animal, things like that, playing with your kids.

What about, is that still connected then to our nervous system? How would you get out of a dysregulated nervous system?

Cannon had a long abiding interest in the physiology of emotion.

He was the pioneer of the sympathetic nervous system, the SNS.

He was the one looking at the immediate short term fight or flight responses, wasn't he?

Exactly.