symmetric dimethylarginine
Chemical compoundWikipedia
23
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4
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Search complete. 23 mentions across 4 episodes found for "symmetric dimethylarginine".
Sep 17, 2026
Audrey CookGUEST
If they've got small kidneys on physical, that's a big clue.
Audrey CookGUEST
As far as lab data that we can refer to, there has been some work that said that if you measure SDMA pretreatment, if that is above the reference range, there's a really good chance that cat is going to have obvious chronic kidney disease when you have addressed its hyperthyroidism.
Audrey CookGUEST
A normal pretreatment SDMA doesn't preclude that, but an increased pretreatment SDMA is a pretty good clue that you're probably going to see that creatinine move up when you successfully address with thyroid disease.
Beth MollisonHOST
And I want to ask you a little bit about the early treatment and management, Dr. Cook.
Beth MollisonHOST
And of course, when it comes to treatment, we know we have options.
Silent Signals—Uncovering Renal Disease on Routine Chemistry
Sep 17 · 14 Mentions
Elizabeth SchooleyGUEST
There's kind of three that definitely come to the top of my mind.
Elizabeth SchooleyGUEST
First thing, of course, is elevation in SDMA, even if it's fairly mild, you know, somewhere in that 15 to 19 micrograms per deciliter.
Elizabeth SchooleyGUEST
area is still something that I want to keep my eyes out for.
Elizabeth SchooleyGUEST
Or any kind of persistent rise in SDMA above the patient's typical baseline, even if it's before creatinine changes.
Elizabeth SchooleyGUEST
Number two is I'm always going to be looking for a rising creatinine trend.
Elizabeth SchooleyGUEST
And so while it may still technically be within the reference interval, you can still have early kidney disease if your creatinine is just slowly rising over time.
Elizabeth SchooleyGUEST
hydration in the pre-anesthesia all the way through the post-anesthesia time period.
Elizabeth SchooleyGUEST
I think those are all ways that we can minimize the risk if needed.
Natalie FinchGUEST
So using a cat where it serves as its own baseline to look for progressive increase in creatinine concentration that might alert us to the possibility of either progressive disease or the development of azotemic chronic kidney disease.
Samantha TaylorGUEST
Ten years ago, we did have SDMA available.
Natalie FinchGUEST
And at that time, the initial studies were suggesting that SDMA had a greater detection for decreased renal function than creatinine.
Natalie FinchGUEST
But we've had lots more studies since that time.
Natalie FinchGUEST
And so now we know that actually the correlations between SDMA and GFR and creatinine and GFR are probably similar.
Natalie FinchGUEST
SDMA is less affected by muscle mass than creatinine.
Natalie FinchGUEST
And so it can be beneficial when we're using it in those cats with chronic kidney disease that may have lost muscle mass, those underweight cats.
Natalie FinchGUEST
So perhaps we want to consider SDMA in our interpretation of our renal profile more in those cats.
JayHOST
Right.
Judy MorganGUEST
You have to see a urinalysis, and you have to look at BUN, and you have to look at creatinine, and you have to look at phosphorus, and you have to look at the CBC, and you have to look at the SDMA.
Judy MorganGUEST
Like, you can't say, "Oh look, his creatinine was 1.8. That's out of the normal." And then you look at everything else and you go, "And it's perfectly normal and his ki- his urine is concentrated out the wazoo.
Judy MorganGUEST
Where, where's the kidney failure? Wait, I, I, I lost it." So, you know, a lot of time...
Judy MorganGUEST
The BUN is almost always higher.
Judy MorganGUEST
If you're feeding a high protein diet, you're gonna get a higher BUN, so then your vet says, "Oh, he's in kidney failure 'cause his BUN is 38." But that's normal for...
Judy MorganGUEST
Look, his urine's well concentrated and his creatinine is normal and his SDMA is seven.
Judy MorganGUEST
Yeah, not in kidney failure.