Sulfite oxidase

So we have to look at, there's so many different pathways that histamine breaks down through.

So we have our what's called the DAO pathway that some people have heard of, an HNMT pathway, which is a methyl pathway, but then we have other things, like we have a SUOX pathway, a MAO pathway, a NAT pathway.

And I'm throwing out a lot of mumbo jumbo language.

That's not what's important.

it converts it through to sulfite.

And then a specific enzyme called sulfite oxidase or SUOX, converts that sulfite into sulfate, which is safe and easily cleared out.

And SUOX needs molybdenum as a cofactor to actually do that conversion.

And a lot of people are deficient in molybdenum.

So two of the most common reasons this clearance step breaks down are having a less efficient variant of the SUOX gene or simply being deficient in molybdenum.

Either way, when clearance is compromised, the conversion bottlenecks.

Hydrogen sulfide can't be neutralized fast enough and it accumulates to a point where it starts causing that mitochondrial damage I described.

And in my own practice, oregano is the one I reach for pretty much every time because it's broad spectrum and in my clinical experience, really effective for bringing down these sulfur-producing bacteria, both the sulfate reducers and the cysteine degraders.