And these were the three questions that were enrolling at the launch of this prepare trial that migrated in name to REMAP-CAP in a factorial experiment.

There was an initial protocol, um, which, um, to the best of my recollection, uh, did get us, uh, recruiting in a small number of locations that didn't include Australia at that stage.

But I think it was apparent that, um, the protocol that had been written initially was, um, uh, w-was a standalone master protocol containing everything.

And if one looked as to how this is going to evolve, adapt, new questions coming in, um, there was a feeling that this sort of, um, single protocol document wasn't going to be, uh, effective over time.

And that led us to the development of the modular protocol, which, uh, we've used, I think, quite successfully ever since.

And the principle here is to have a core or master protocol that contains the eligibility criteria at platform level and the primary endpoint that's going to be used at platform level across, uh, all of, uh, the domains.

Little bit about the disease of interest in terms of background.

Yeah