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Stephen Hoge
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Oct 20, 2026
Moderna’s Dr. Stephen Hoge on AI and the Future of Healthcare
15:33
15:41
15:27
So give us just the real quick layman's take of what that news was, what happened.

Stephen HogeGUEST
Well, I'll describe it in the context of the phase two trial because the phase three results are coming out and we've pointed that phase two.

Stephen HogeGUEST
There have been a revolution in melanoma treatment over the last couple decades with these antibodies called PD-1 or immunotherapy.
18:41
I mean, how do you do this? Create an individualized medicine for each and every person?
388: The FDA's refusal to review Moderna's mRNA flu vaccine
16:00
16:12
16:17
16:23
22:36
15:33
Stephen, what does the path forward look like from here on out? I mean, is it that you amend the application to specify that this vaccine would ideally only be for patients 50 to 64 years of age? Do you go back and do you try to run additional trials in older patients against that comparator arm that they want? I mean, it seems like you need to find some sort of way to work with this administration.

Stephen HogeGUEST
Again, we we need to sit down and understand what is the specific scientific objection they have to even conducting the review.

Stephen HogeGUEST
They'd agreed that they would look at it and they agreed that this phase three trial was adequate 18 months ago.

Stephen HogeGUEST
Our first step is we just we would appreciate a scientific dialogue about the data in the file.

Stephen HogeGUEST
And, you know, I don't know actually even how to anticipate what what they're asking for.
6 MINS LATER
Matthew HerperGUEST
What does that show? And do you think that might add any clarity here? I assume it's already in the submission, but.
