
Stephan Isaac
Assistant Professor of Biochemistry & Cell Biology at Boston University School of Medicine, studying mitochondrial genome packaging, regulation, and aging.
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Aug 3, 2026
Can We Reprogram Aging Through Mitochondria? | Dr. Stefan Isaac
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20:36
George MurphyHOST
Can you tell us a little bit about that and what are the consequences of, uh, mutations maybe occurring in your normal somatic DNA versus your mitochondrial DNA?

Stephan IsaacGUEST
So essentially, um, you know, you have these multiple compartments in your cell.

Stephan IsaacGUEST
Most of the DNA that I think we think about is in the nucleus that's, you know, comes as a mixture from, you know, two parents.

Stephan IsaacGUEST
Mitochondrial DNA is inherited solely from the mother, so it's in the oocyte, and, um, it is not transferred from the sperm during fertilization, and it's an incredibly small genome.

Stephan IsaacGUEST
So to give a scale, it's like sixteen thousand letters of information versus about six billion pieces of information.
10 MINS LATER
George MurphyHOST
What about artificially or just mitochondrial transfer or transplantation in and of itself? How would something like that work? So how would you, even from a rudimentary point of view of isolation of mitochondria, say from a young cell, and then, or young cells, and then delivering that into a particular target cell or tissue, how would something like that work?