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Sriram Kosuri

Researcher

Aug 25, 2026

3:47
What led you to concentrate there?
3:50
This goes back to the lessons of what we were naive about and what we weren't, right? We had started with this idea in dirty drugs in, uh, a class of receptors called GPCRs, where there's a lot of polypharmacology where a small molecule can hit many things, and that's essential for their function, and bias, which is multiple pathways off the same target.
4:10
We switched largely because we began to realize that if we wanted to build scale and our own commercial drugs, it's really hard to do that in a large, complex disease area.
4:22
Your only option really is to transact the asset where value and flex.
4:26
And we are trying to build a company that can build scale over time.
4:30
What we saw was small molecule correctors that we landed on are more protectable in the sense that they're really hard to build.
4:36
No one else has really good ways to build them.
8:33
What actually is happening inside the platform when you run one of these experiments, and why is it so unique?
4:16
Well, so for those who aren't familiar with this, can you just tell the story in short? Sure.
4:23
Yeah, you know, around Thanksgiving in 2024, my daughter started developing a swelling above her eye, her left eye.
4:36
And, you know, we went to the pediatrician.
4:38
They thought it was a stye.
4:40
We iced it and it just kept on getting worse.
4:43
My brother got married in mid-December.
4:45
We went there and it was just getting worse and worse.

36 MINS LATER

40:37
What was in those models that simulated this to a high degree of accuracy?

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