SOD2

But it's important because if you have a gene-- Like, I literally just got off the phone with somebody who has a hemochromatosis gene, and they have a superoxide dismutase gene.

It's called SOD2.

Hmm.

And that SOD2 gene is a tenfold higher risk of heart disease if your iron is high.

It's only a risk-

Wow

Then we have good old mitochondrial quality control, whereby humanin has been shown after TBI to normalize disruptions in mitochondrial fusion, fission, mitophagy, and biogenesis, including pathways involving PGC1 alpha.

Oxidative stress protection, whereby humanin influenced antioxidant defenses such as SOD2 or SOD2 and has a broader literature supporting protection against oxidative stress and mitochondrial injury.

Then we have anti-apoptotic and neuronal survival signaling, whereby humanin is well-characterized as a cytoprotective and anti-apoptotic peptide and has been studied for protecting neurons from multiple forms of cellular stress.

And then last but certainly not least, we have neurodegenerative resilience, whereby human was originally identified through its ability to protect neurons from Alzheimer's-associated insults, and subsequent research has explored roles in amyloid toxicity, neuroinflammation, autophagy, and mitochondrial dysfunction.

... taking in excess oxygen, then you're making more soot without the ability to neutralize it into water and pee it out, which is what happens through hydrogen oxide, peroxide synthesis.

So that's the SOD2 gene pathway.

So that was one thing he had going on.

Now, after we know it's accumulating because of the excess oxidation of his habit of exercise and the genetics of not being able to process the oxidation, there's a second pathway that uses glutathione, this molecule that we all talk about, this, uh, detox tool, to remove whatever got left over, and that gene he was missing.