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Sildenafil

Sildenafil

MedicationWikipedia

Search complete. 1146 mentions across 601 episodes found for "Sildenafil".

Sep 16, 2026

Ben MacintyreGUEST
11:20
Now, of course, there was no magic cure.
Ben MacintyreGUEST
11:22
There was no-- Viagra had not been invented.
Ben MacintyreGUEST
11:24
There was no pill that was gonna make this better.
Ben MacintyreGUEST
11:26
Kozichin believed there was, but there wasn't.
Todd ChrisleyHOST
18:19
Right.
Todd ChrisleyHOST
18:19
And they're like, well, I order, you know, I order this Cialis or Viagra.
Todd ChrisleyHOST
18:24
I ordered anonymously.
Todd ChrisleyHOST
18:25
So that way, when it comes to my mailbox, nobody knows.
Nathan S. BryanGUEST
19:47
And cyclic GNP is the second messenger that tells the smooth muscle to relax.
Nathan S. BryanGUEST
19:53
And some of you are familiar with this, maybe not the detailed biochemistry, but Viagra.
Nathan S. BryanGUEST
19:58
the drugs for erectile dysfunction, they prevent the breakdown of the second messenger cyclic GMP.
Nathan S. BryanGUEST
20:04
These are called phosphodesterase inhibitors.
Nathan S. BryanGUEST
20:06
Phosphodesterase enzymes break down cyclic GMP.
Nathan S. BryanGUEST
20:09
If you inhibit that, then it leads to an accumulation of cyclic GMP.
Nathan S. BryanGUEST
20:13
So nitric oxide turns the switch on and Viagra keeps it on.
Nathan S. BryanGUEST
20:18
And that's why you're warned against the four-hour erections.
Coby BullGUEST
41:15
I bought that.
Coby BullGUEST
41:15
At the same time, I bought Hugh Hefner's used Viagra bottle, which I thought was really funny.
Coby BullGUEST
41:21
That's crazy.
Coby BullGUEST
41:22
Where do you display things like that? Sadly, you can't display these items safely in London because you're such a target.

41 MINS LATER

Coby BullGUEST
82:06
Okay, so I'll tell you a couple things.
Coby BullGUEST
82:08
My whole philosophy on collecting is that if it means something to me, there's more people like me out there in this big world of ours, and it means something to them.
Coby BullGUEST
82:18
So, I mean, I could talk about Hugh Hefner's Viagra.
Coby BullGUEST
82:22
I could talk, which I think is a hysterical piece.
Holly RichmondGUEST
31:42
But I also want the men out there to hear there are also really great medical solutions that are just keep getting better and better and better every year.
Holly RichmondGUEST
31:53
So we all know about Viagra and CLS, but there's a new pill, but it's something you put under your tongue on the market that combines sildenafil, tildenafil, and apramorphine.
Holly RichmondGUEST
32:07
And the apramorphine is that little bit of the feel good, right? A little bit of the serotonin, a little bit of the dopamine, and this is all in one tablet.
Holly RichmondGUEST
32:15
Yeah.
Holly RichmondGUEST
32:25
And I know this freaks guys out a lot, but it's not nearly as scary as it sounds.
Holly RichmondGUEST
32:30
And again, it's 95% effective.
Holly RichmondGUEST
32:33
So Jacqueline, I'm just saying all this because so many men come to me and they've tried, they feel like I have the Cialis prescription, I have the Viagra prescription, and it's not working for me.
Holly RichmondGUEST
32:44
And they're so hopeless.
KekeHOST
24:14
It
Zach BoogHOST
24:14
turned you up like Viagra.
Zach BoogHOST
24:16
I'm talking, but I just feel like new.
Zach BoogHOST
24:18
Oh, like a new person? Like Adderall? He took some
Reni MaituaHOST
26:31
Yeah, I know.
Reni MaituaHOST
26:32
You need a Camagra, Cialis, Viagra.
Braith AnastaHOST
26:35
You need all three
Reni MaituaHOST
26:36
just to rev you up.
Ben MacintyreGUEST
52:10
the problem was that of course there was no cure.
Ben MacintyreGUEST
52:13
Viagra had not been invented and would not be invented for another 14 years, but he didn't know that.
Ben MacintyreGUEST
52:21
And the Brits, said, well, look, we took him on and said, we'll do our best.
Ben MacintyreGUEST
52:26
But they knew there was no cure for this at that point.

6 MINS LATER

Ben MacintyreGUEST
58:49
So this is one of those strange stories.
Ben MacintyreGUEST
58:53
It's a story about one man's deeply personal individual problem, you know, and its impact, its massive impact on the world that we live in today.
Ben MacintyreGUEST
59:06
If Kuzichkin, if Viagra had been invented and Kuzichkin hadn't had a problem, Who knows? The story of the Cold War could have been completely different.
Jack CarrHOST
59:17
Incredible.
Max Van HosenPANELIST
35:42
really? And then they end up.
Lily Ritterman-PeñaHOST
35:44
and then they end up in the lighthouse and they're like making out and it's all like steamy it's like ooh something's gonna happen and they're like actually let's not let's not like be boxed in by this mandate like you're not just like you're not just like meat like whatever for like the day like i want i think let's not rush it this is a real connection like we don't have to crack right now at the lighthouse and then they're like you don't have to crack babe babe you don't have to crack and then they're like yeah that's beautiful and then they realize because the whole premise the whole time well it's not the premise but the whole time Joan Baez like her day job is like singing uh parody songs of like like medications and then I thought it was funny I thought it was but they had like they were they were like filming a commercial for like something that has her voice and it was like You wanna take Viagra? It's like something like that.
Lily Ritterman-PeñaHOST
36:37
I don't even know.
Lily Ritterman-PeñaHOST
36:38
But it's basically like one of those like medical parries like Ozempic.
Eli AmdurHOST
19:42
Aphorism number two, here's how I know I'm getting old.
Eli AmdurHOST
19:47
I used to get targeted ads from Viagra.
Eli AmdurHOST
19:51
Now, it's no more of that.
Eli AmdurHOST
19:53
It's walk-in bathtubs and prepaid funerals.

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