Side effect
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Search complete. 453 mentions across 84 episodes found for "Side effect".
Sep 12, 2026
LucasHOST
Now, sometimes medicine makes you sleepy or causes other issues.
LunaHOST
Side effects.
LunaHOST
Yes.
LunaHOST
I always check that.
LucasHOST
It is smart.
LucasHOST
So you ask, are there any side effects?
LunaHOST
This one is longer.
LunaHOST
Let me listen first.
Jen TrepekHOST
chronic kidney disease I'll mention again, cardiovascular risk reduction, osteoarthritis of the knee, and even chronic lower back pain.
Jen TrepekHOST
So it's showing similar gastrointestinal side effects as other GLP-1 medications like diarrhea, nausea, vomiting, constipation tend to be the most common.
Jen TrepekHOST
I personally have seen more dramatic impacts especially sort of the snowball of constipation, slower gastric emptying, and that in combination with some other food choices can exacerbate some of these side effects.
Jen TrepekHOST
One of the biggest questions with Reta-Truetide is if it will support people whose bodies didn't respond to the other pharmaceuticals.
Jen TrepekHOST
So right now, it's about 10% of people who are not responding to other GLP-1 meds, whether it's first generation or second generation.
Nichole Jackson-LindHOST
then maybe you have to slow your roll with the titration process.
Nickie LovatHOST
And that's where I think that estradiol dosing is more complicated and individualized because you can miss the mark with all the other hormones by a wide margin and people don't really get side effects.
Nickie LovatHOST
Right.
Nickie LovatHOST
estradiol isn't is a one where you will if you go too fast you will produce side effects and women the number one reason they stop estrogen is bleeding and it wasn't even right a problem in fact the bleeding from estrogen when you start it typically if you do have a uterine cancer it's been there for five to ten years and we made it bleed so we caught it early we're not causing any uterine cancer in short-term dosing changes but a lot of women stop it thinking I'm bleeding.
Nickie LovatHOST
There's a problem.
Nichole Jackson-LindHOST
Right.
JasmineHOST
Yeah.
JasmineHOST
because i know that one of the other reasons why people tend to lose a lot of weight when they take it is there are quite a few side effects that would also make you lose weight because it also has been known to cause diarrhea and make you feel really nauseous and like those two are typically things that would make you lose weight probably not i mean the nausea would make you lose fat but the diarrhea that's just water weight and also fat because you're not eating a
EllieHOST
Yeah, I guess if you feel sick, then you're
LauraHOST
going to just eat less anyway, aren't you? You say that.
7 MINS LATER
JasmineHOST
So in 10 years' time, we'll have the answers, hopefully, to most of these questions.
LauraHOST
Ah, more science.
EllieHOST
yes more data maybe they would have figured out more about food noise who knows do you think it would be something you could tolerate like we've talked about this perhaps not the best like method like you lose weight very quickly but it's lots of food noise but you might get all these side effects would that be something that you were willing to put up with if that was your goal
JasmineHOST
I mean, personally, no, because part of how GLP-1 works is it makes you not want to eat food because you don't feel hungry, your brain's not telling you to eat some chocolate, but also it can make you feel really sick, so I'd rather not feel really bad.
Donal O'SheaGUEST
Yeah, I mean, I think it would be to, you know, emphasise this is a new treatment for you.
Donal O'SheaGUEST
And the main side effects in the early phase is around nausea, around constipation, perhaps a bit of dizziness.
Donal O'SheaGUEST
So plenty of fluids, high fibre diet.
Donal O'SheaGUEST
reinforcing the need to be active.
17 MINS LATER
Donal O'SheaGUEST
And the two reasons for stopping are, well, there's three.
Donal O'SheaGUEST
One, it doesn't work.
Donal O'SheaGUEST
Two, side effects.
Donal O'SheaGUEST
And then third is cost.
Adam SchellGUEST
Um, they make a blend of seven different forms of magnesium that are really beneficial.
Adam SchellGUEST
So those are the biggest counterindications and, and sometimes occasional side effects, and it's all remedied by that list that I just went through.
Amrit SandhuHOST
through.I find it, the, um, the canary in the coal mine point is interesting because even as you said, um, earlier, sometimes just, you know, if you're feeling, I don't wanna say the blues or whatever, you know, but whatever, like, you know, getting the energy before the actual task at hand.
Amrit SandhuHOST
I mean, these are probably things n- like water, hydration, salts, minerals, is li- very likely something that is important for people as is that they may not-
ChadHOST
Mm-hmm.
NikkiHOST
How does that look in practice? Like what side effects might my child have? Um, what might be the benefits? How would I know it's helping? How would I know it's not helping, right? Ask those things on the front end, and until you feel comfortable saying yes, it's okay to, you know, hold off.
ChadHOST
Yeah.
NikkiHOST
That happens a lot.
ChadHOST
Okay.
ChadHOST
Um, side effects.
NikkiHOST
Mm-hmm.
ChadHOST
Is that part of the bad, or is that part of the ugly?
Michael BaxterHOST
We've heard a lot about the benefits for diabetes, weight loss.
Michael BaxterHOST
When we come back, we're gonna talk about some of the risks of these medicines, side effects, and then I'm gonna bring Dr. Santoro in to talk, and we'll begin to talk about some of the other potential benefits of these medications, and maybe they are the numerical drugs.
Michael BaxterHOST
Anyway, we're gonna take a break, and then we'll be right back to Health Talk.
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Michael BaxterHOST
When we left, I said we were going to come back and we talked about all these benefits.
Michael BaxterHOST
There's got to be some downsides.
Michael BaxterHOST
Are there some risks, side effects to these medications, Jerry, and how much should people be concerned about these?
Jerome LazarGUEST
Well, there are certain conditions where you would not want to use this medication, one of which if there's a family history of medullary thyroid cancer.
Bryana BurkenHOST
Not a bad thing, just a different type of dosage form, which is something we have to account for.
Bryana BurkenHOST
So if the patient's gut is not healthy, if the person is more sensitive and they tend to have more side effects when they try new things, then this can be a nice option because, again, it is circumventing that system.
Bryana BurkenHOST
Again, no injection is required, right? So one type of route of administration that we talk about a lot is injectable testosterone.
Bryana BurkenHOST
It's very well known.
12 MINS LATER
Bryana BurkenHOST
Now, again, 90% bioavailability, so probably somewhere around 90-ish milligrams throughout the week, but it's going to vary person to person.
Bryana BurkenHOST
All right.
Bryana BurkenHOST
Let's go ahead and wrap it up with some common side effects and just some things to keep in in mind for monitoring and discussing with your physician.
Bryana BurkenHOST
So just like anything, we're all about balance.
Leslie SchlachterHOST
Okay? And they have dramatically cha-- I mean, my patients' world, they've dramatically changed so many people with weight loss, but also muscle loss.
Leslie SchlachterHOST
One of the biggest side effects of the GLPs are is it cuts down your hunger, so you don't wanna eat as much.
Leslie SchlachterHOST
Now, I know there's a lot of people that see dieticians that you guys take care of people who need to lose weight, right? But there's a smart way of losing weight and the not smart way of losing weight.
Eugenia HamshawGUEST
Totally.
9 MINS LATER
Leslie SchlachterHOST
Right
Eugenia HamshawGUEST
... because you need it to work hard for you.
Leslie SchlachterHOST
How can people utilize food to combat the known side effects of GLPs, right? So, like, people complain of nausea, diarrhea, but also constipation.
Leslie SchlachterHOST
There's people that get diarrhea.
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