Sharon H Bergquist
Researcher
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Sep 2, 2026
ENCORE: Turning Stress into Strength, Part 1
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22:58Ronald HoffmanHOST
So, can you explain the physiology that links all these diverse ailments to stress?
Sharon BergquistGUEST
Yeah, and that's really the heart of the question because there is a common root.
Sharon BergquistGUEST
And if we approach any health aspect or even longevity from treating the underlying processes, it is really the most elegant way to approach our health and by far the most efficient.
Sharon BergquistGUEST
And if there's cellular dysfunction, for example, if our mitochondria, which are the parts of our cells that make energy, are impaired, our cells cannot make the energy they need to do any of their functions.
Sharon BergquistGUEST
Our cells are so sophisticated, they not only house our DNA in the nucleus, they also have manufacturing plants called ribosomes where we make proteins, and we have 20,000 to 100,000 proteins that do the work inside our body, inside our cells.
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26:18Ronald HoffmanHOST
But the brain also sends signals via the vagus nerve, I guess, traded a two-way highway to the gut that can then signal the propensity to harbor bad bugs, you know, a lack of of diversity of, in your microflora.
ENCORE: Turning Stress into Strength, Part 2
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5:17speaker_2ADVERTISER
Right.
Sharon BergquistGUEST
we raise our autophagy, we stimulate mitochondrial biogenesis, we make new mitochondria.
Sharon BergquistGUEST
All of these increase our resistance so that we became more able to consume plant foods.
Sharon BergquistGUEST
And we have seven cellular stress responses, and together they do what I call the four R's.
17 MINS LATER
The Stress Paradox: How Food, Stress & Hormesis Help Us Age Better | Dr. Sharon Bergquist
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Sophie UlianoHOST
And so, uh, can you explain to our listeners and viewers what phytochemicals actually are?
Sharon BergquistGUEST
And, and I'll put what I'm about to say in the context of really how I came about the, the good stressors that we're talking about, including the phytochemicals.
Sharon BergquistGUEST
So, you know, my work as a physician is I get to see my patients over time, kind of longitudinally, and to see how the impact of their behaviors or choices and decisions play out in their health, um, and, and any complications they have over time.
Sharon BergquistGUEST
And after being in practice, um, I have been in practice, in the same practice now for 26 years, but about a decade in, I realized that even though my patients were well-controlled in terms of their blood sugar, their blood pressure, all their numbers, that the underlying process of what, um, they were dealing with was getting worse.
19 MINS LATER
Dr. Sharon Horesh Bergquist, MD: Hormetic Stress, Women’s Resilience, and the 5 Stressors That Support Longevity
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So it just has to be all the combination, right? It's like a tidal wave of just stressors, physical, mental.
14:00
And you bring up really a wonderful point, which is what is culture and what is really an intrinsic need of our biology, right? We are at a point where our culture is so counter to what our biological needs are that the default is disease.
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And when it's the predominant culture, it's very hard to be counterculture.
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But I hope what we can bring to light is how do we honor our bodies? A lot of my approach to stress is really looking at how do we reverse engineer the life we're meant to live based on our DNA, based on our body's regenerative and healing capacity.
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And when we realize what a tremendous ability we have to regenerate and heal, we can then work backwards and say, okay, these are the non-negotiable elements in our lifestyle that we need.
35 MINS LATER
49:52
So what does that look like? You said a minimum of 12 hours, right? And is fasting okay for women too? Let's throw that question in there while we're here.
Water vs. Tech: How Moisture Ruins Your Devices & Why We Need Stress
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47:05Mike CarruthersHOST
You're focused on the good stress wh- b- but is there something to managing your bad stress?
Sharon BergquistGUEST
The, there's no question that the bad stress, or the chronic harmful stressors chip away at our health.
Sharon BergquistGUEST
And to the extent that we can control these bad stressors or even strategically plan for recovery so that we can lower the effects of the chemicals that are released that cause the harm, there's clear benefit to that.
Sharon BergquistGUEST
That is stress management if really historically, and that is the common approach.
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52:07Mike CarruthersHOST
The, the benefits of the good stress are health benefits and other benefits, but talk specifically about how they mitigate the bad stress.

